The interrelationships of glycemic control measures: HbA1c, glycated albumin, fructosamine, 1,5-anhydroglucitrol, and continuous glucose monitoring

Roy Beck, Dongyuan Xing, Katrina Ruedy, Nelly Mauras, Darrell M. Wilson, Craig Kollman, H. Peter Chase, Rosanna Fiallo-Scharer, Laurel Messer, Eva Tsalikian, Michael J. Tansey, Julie Coffey, Joanne Cabbage, Tim Wysocki, Nelly Mauras, Larry A. Fox, Keisha Bird, Kim Englert, Bruce A. Buckingham, Darrell M. WilsonPaula Clinton, Kimberly Caswell, Stuart A. Weinzimer, William V. Tamborlane, Amy Steffen, Roy W. Beck, Katrina J. Ruedy, Craig Kollman, Dongyuan Xing, Alyssa Baptista, Michael W. Steffes, Jean M. Bucksa, Maren L. Nowicki, Carol A. van Hale, Vicky Makky, Gilman D. Grave, Mary Horlick, Karen Teff, Karen K. Winer

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

Objectives: To describe the interrelationships of glycemic control measures: hemoglobin A1c (HbA1c), glycated albumin, fructosamine, 1,5-anhydroglucitrol (1,5-AG), and continuous glucose monitoring (CGM) in children and adolescents with type 1 diabetes. Methods: In total, 26 subjects of age 4-17 had HbA1c measurement followed within 14 d by three laboratory measures of glycemia and the collection of CGM glucose data (N = 21). Results: Glycated albumin and fructosamine levels had a higher correlation with each other than with HbA1c. The correlation of 1,5-AG with HbA1c was lower (absolute r value = 0.25). All four measures had a similar degree of correlation with CGM-measured mean glucose (absolute r value = 0.50-0.56) and with hyperglycemic area under the curve (AUC) at 180 mg/dL (0.50-0.60). Conclusion: Each of the four measures (i.e., HbA1c, glycated albumin, fructosamine, and 1,5-AG) had a similar correlation with mean glucose and hyperglycemic AUC-180. 1,5-AG did not correlate with hyperglycemic AUC-180 better than did HbA1c.

Original languageEnglish (US)
Pages (from-to)690-695
Number of pages6
JournalPediatric Diabetes
Volume12
Issue number8
DOIs
StatePublished - Dec 2011

Keywords

  • 1,5-AG
  • Hemoglobin A1c
  • Type 1 diabetes mellitus

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