The International Childhood Cardiovascular Cohort (i3C) consortium outcomes study of childhood cardiovascular risk factors and adult cardiovascular morbidity and mortality: Design and recruitment

Alan R. Sinaiko, David R. Jacobs, Jessica G. Woo, Lydia Bazzano, Trudy Burns, Tian Hu, Markus Juonala, Ronald Prineas, Olli Raitakari, Julia Steinberger, Elaine Urbina, Alison Venn, Cashell Jaquish, Terry Dwyer

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Although it is widely thought that childhood levels of cardiovascular (CV) risk factors are related to adult CV disease, longitudinal data directly linking the two are lacking. This paper describes the design and organization of the International Childhood Cardiovascular Cohort Consortium Outcomes Study (i3C Outcomes), the first longitudinal cohort study designed to locate adults with detailed, repeated, childhood biological, physical, and socioeconomic measurements and a harmonized database. I3C Outcomes uses a Heart Health Survey (HHS) to obtain information on adult CV endpoints, using mail, email, telephone, and clinic visits in the United States (U.S.) and Australia and a national health database in Finland. Microsoft Access, REsearch Data Capture (REDCap) (U.S.), LimeSurvey (Australia), and Medidata™ Rave data systems are used to collect, transfer and organize data. Self-reported CV events are adjudicated via hospital and doctor-released medical records. After the first two study years, participants (N = 10,968) were more likely to be female (56% vs. 48%), non-Hispanic white (90% vs. 80%), and older (10.4 ± 3.8 years vs. 9.4 ± 3.3 years) at their initial childhood study visit than the currently non-recruited cohort members. Over 48% of cohort members seen during both adulthood and childhood have been found and recruited, to date, vs. 5% of those not seen since childhood. Self-reported prevalences were 0.7% Type 1 Diabetes, 7.5% Type 2 Diabetes, 33% hypertension, and 12.8% CV event. 32% of CV events were judged to be true. I3C Outcomes is uniquely able to establish evidence-based guidelines for child health care and to clarify relations to adult CV disease.

Original languageEnglish (US)
Pages (from-to)55-64
Number of pages10
JournalContemporary Clinical Trials
Volume69
DOIs
StatePublished - Jun 2018

Bibliographical note

Funding Information:
The results presented herein represent progress through the initial two years of study funding, i.e., from December 1, 2014 through December 31, 2016. The study is funded through November 30, 2019. Based on experience by each of the cohort Principal Investigators, it was anticipated that the sites would be able to locate approximately 31,000 of the approximately 40,000 total cohort members and that approximately 22,000 would agree to participate in this study, i.e., complete the HHS ( Table 2 ).

Funding Information:
This work was supported by the National Institutes of Health (grant number RO1HL121230 ).

Publisher Copyright:
© 2018 Elsevier Inc.

Keywords

  • Adult Cardiovascular disease
  • Childhood cardiovascular risk factors
  • Collaborative cohort study
  • Heart health survey
  • Longitudinal cardiovascular risk study

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