The interactive effects of child maltreatment and the FK506 binding protein 5 gene (FKBP5) on dissociative symptoms in adolescence

Fatima Tuba Yaylaci, Dante Cicchetti, Fred A. Rogosch, Okan Bulut, Susan R Hetzel

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

The FK506 binding protein 5 gene (FKBP5) has been associated with susceptibility to pathogenic effects of childhood trauma including dissociative symptoms. This study examines the impact of maltreatment on dissociative tendencies in adolescence as moderated by the FKBP5 gene. Dissociative symptoms and variation within FKBP5 were assessed in a high-risk, low socioeconomic status community sample of 279 maltreated and 171 nonmaltreated adolescents. Following the assignment of haplotypes across four single nucleotide polymorphisms (rs3800373, rs9296158, rs1360780, and rs9470080), individuals with one or more copies of the CATT haplotype (N = 230) were grouped together and compared to individuals with zero copies of this haplotype (N = 185). Analyses of covariance were conducted to test hypotheses regarding the effects of developmental timing and the chronicity of maltreatment and the CATT haplotype. We found a significant interactive effect of timing/chronicity of maltreatment and the CATT haplotype on dissociative symptoms. Among adolescents who had no copies of the CATT haplotype, dissociative symptoms were higher for chronically maltreated adolescents who had an infancy onset compared to those who were not maltreated or whose maltreatment experience was either relatively less chronic or not started in infancy. The groups did not differ significantly among subjects who carry one or more copies of the CATT haplotype.

Original languageEnglish (US)
Pages (from-to)1105-1117
Number of pages13
JournalDevelopment and psychopathology
Volume29
Issue number3
DOIs
StatePublished - Aug 1 2017

Bibliographical note

Funding Information:
This research was supported by funding from the National Institute on Drug Abuse (DA12903) and the Spunk Fund, Inc.

Publisher Copyright:
© Cambridge University Press 2016.

Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.

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