The ins and outs of mitochondrial calcium

Toren Finkel, Sara Menazza, Kira M. Holmström, Randi J. Parks, Julia Liu, Junhui Sun, Jie Liu, Xin Pan, Elizabeth Murphy

Research output: Contribution to journalReview articlepeer-review

185 Scopus citations


Calcium is thought to play an important role in regulating mitochondrial function. Evidence suggests that an increase in mitochondrial calcium can augment ATP production by altering The activity of calcium-sensitive mitochondrial matrix enzymes. In contrast, The entry of large amounts of mitochondrial calcium in The setting of ischemia-reperfusion injury is thought to be a critical event in triggering cellular necrosis. For many decades, The details of how calcium entered The mitochondria remained a biological mystery. In The past few years, significant progress has been made in identifying The molecular components of The mitochondrial calcium uniporter complex. Here, we review how calcium enters and leaves The mitochondria, The growing insight into The topology, stoichiometry and function of The uniporter complex, and The early lessons learned from some initial mouse models that genetically perturb mitochondrial calcium homeostasis.

Original languageEnglish (US)
Pages (from-to)1810-1819
Number of pages10
JournalCirculation research
Issue number11
StatePublished - May 22 2015
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2015 American Heart Association, Inc.


  • Calcium signaling
  • Cell death
  • Mitochondria


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