The inhibitory effect of polysaccharides isolated from Phellinus linteus on tumor growth and metastasis

Sang Bae Han, Chang Woo Lee, Young J Jeon, Nam Doo Hong, Ick Dong Yoo, Kyu Hwan Yang, Hwan Mook Kim

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192 Scopus citations

Abstract

It was previously reported that polysaccharides (PL) isolated from Phellinus linteus strongly stimulated cell-mediated and humoral immunity. This study was undertaken to investigate the immunochemotherapeutic activity of PL against tumor growth and metastasis. PL alone significantly prolonged the survival rate of B16F10-implanted mice, inhibited tumor growth in NCI-H23-implanted nude mice, and reduced the frequency of pulmonary metastasis of B16F10 melanoma. Adriamycin significantly inhibited tumor growth, but only slightly inhibited metastasis. The combination therapy with PL and adriamycin was more effective in inhibiting tumor growth, but not metastasis. PL did not induce direct toxicity in cancer cells, which is characteristic of immunotherapeutics. In conclusion, PL might be of use in immunochemotherapy of cancer because of its effective activities on tumor growth and metastasis through the immunopotentiation of the patients without toxicity. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)157-164
Number of pages8
JournalImmunopharmacology
Volume41
Issue number2
DOIs
StatePublished - Feb 1 1999

Keywords

  • Adriamycin
  • Immunochemotherapy
  • Metastasis
  • Phellinus linteus
  • Tumor growth

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