The influence of VKORC1 and CYP2C9 mutations on warfarin response after total hip and knee arthroplasty

Eric S. Wise; Stephen P. Gadomski; William G. McMaster; Robert J. Wilson; Justin K. Nelms; Kyle M. Hocking; Colleen M. Brophy

doi:10.1016/j.jor.2015.10.023

The influence of VKORC1 and CYP2C9 mutations on warfarin response after total hip and knee arthroplasty

Eric S. Wise, Stephen P. Gadomski, William G. McMaster, Robert J. Wilson, Justin K. Nelms, Kyle M. Hocking, Colleen M. Brophy

Research output: Contribution to journal › Article › peer-review

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Abstract

Aims: This study characterizes the influence of genotype at two loci on warfarin response after arthroplasty. Methods: 121 postarthroplasty patients given warfarin thromboprophylaxis were reviewed for international normalized ratio (INR) values on the first three days postoperatively. Significant differences among genotypes in INR values on each of the first three postoperative days were assessed. Results: Wild-type patients at both loci (~23% of patients) had yet to reach therapeutic INR (1.5-2.0) by postoperative day three more frequently than those with a mutation conferring hyper-responsiveness (61% vs. 30%; P ≤ .01). Conclusions: Wild-type patients are not anticoagulated in a sufficiently prompt manner after arthroplasty.

Original language	English (US)
Pages (from-to)	S145-S151
Journal	Journal of Orthopaedics
Volume	12
DOIs	https://doi.org/10.1016/j.jor.2015.10.023
State	Published - Aug 1 2015
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2015 Prof. PK Surendran Memorial Education Foundation.

Keywords

Arthroplasty
Deep venous thrombosis
Genetics
Thromboprophylaxis
Warfarin

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10.1016/j.jor.2015.10.023

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title = "The influence of VKORC1 and CYP2C9 mutations on warfarin response after total hip and knee arthroplasty",

abstract = "Aims: This study characterizes the influence of genotype at two loci on warfarin response after arthroplasty. Methods: 121 postarthroplasty patients given warfarin thromboprophylaxis were reviewed for international normalized ratio (INR) values on the first three days postoperatively. Significant differences among genotypes in INR values on each of the first three postoperative days were assessed. Results: Wild-type patients at both loci (~23% of patients) had yet to reach therapeutic INR (1.5-2.0) by postoperative day three more frequently than those with a mutation conferring hyper-responsiveness (61% vs. 30%; P ≤ .01). Conclusions: Wild-type patients are not anticoagulated in a sufficiently prompt manner after arthroplasty.",

keywords = "Arthroplasty, Deep venous thrombosis, Genetics, Thromboprophylaxis, Warfarin",

author = "Wise, {Eric S.} and Gadomski, {Stephen P.} and McMaster, {William G.} and Wilson, {Robert J.} and Nelms, {Justin K.} and Hocking, {Kyle M.} and Brophy, {Colleen M.}",

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year = "2015",

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doi = "10.1016/j.jor.2015.10.023",

language = "English (US)",

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journal = "Journal of Orthopaedics",

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T1 - The influence of VKORC1 and CYP2C9 mutations on warfarin response after total hip and knee arthroplasty

AU - Wise, Eric S.

AU - Gadomski, Stephen P.

AU - McMaster, William G.

AU - Wilson, Robert J.

AU - Nelms, Justin K.

AU - Hocking, Kyle M.

AU - Brophy, Colleen M.

PY - 2015/8/1

Y1 - 2015/8/1

N2 - Aims: This study characterizes the influence of genotype at two loci on warfarin response after arthroplasty. Methods: 121 postarthroplasty patients given warfarin thromboprophylaxis were reviewed for international normalized ratio (INR) values on the first three days postoperatively. Significant differences among genotypes in INR values on each of the first three postoperative days were assessed. Results: Wild-type patients at both loci (~23% of patients) had yet to reach therapeutic INR (1.5-2.0) by postoperative day three more frequently than those with a mutation conferring hyper-responsiveness (61% vs. 30%; P ≤ .01). Conclusions: Wild-type patients are not anticoagulated in a sufficiently prompt manner after arthroplasty.

AB - Aims: This study characterizes the influence of genotype at two loci on warfarin response after arthroplasty. Methods: 121 postarthroplasty patients given warfarin thromboprophylaxis were reviewed for international normalized ratio (INR) values on the first three days postoperatively. Significant differences among genotypes in INR values on each of the first three postoperative days were assessed. Results: Wild-type patients at both loci (~23% of patients) had yet to reach therapeutic INR (1.5-2.0) by postoperative day three more frequently than those with a mutation conferring hyper-responsiveness (61% vs. 30%; P ≤ .01). Conclusions: Wild-type patients are not anticoagulated in a sufficiently prompt manner after arthroplasty.

KW - Arthroplasty

KW - Deep venous thrombosis

KW - Genetics

KW - Thromboprophylaxis

KW - Warfarin

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SP - S145-S151

JO - Journal of Orthopaedics

JF - Journal of Orthopaedics

ER -

The influence of VKORC1 and CYP2C9 mutations on warfarin response after total hip and knee arthroplasty

Abstract

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