The influence of VKORC1 and CYP2C9 mutations on warfarin response after total hip and knee arthroplasty

Eric S. Wise, Stephen P. Gadomski, William G. McMaster, Robert J. Wilson, Justin K. Nelms, Kyle M. Hocking, Colleen M. Brophy

Research output: Contribution to journalArticlepeer-review

Abstract

Aims: This study characterizes the influence of genotype at two loci on warfarin response after arthroplasty. Methods: 121 postarthroplasty patients given warfarin thromboprophylaxis were reviewed for international normalized ratio (INR) values on the first three days postoperatively. Significant differences among genotypes in INR values on each of the first three postoperative days were assessed. Results: Wild-type patients at both loci (~23% of patients) had yet to reach therapeutic INR (1.5-2.0) by postoperative day three more frequently than those with a mutation conferring hyper-responsiveness (61% vs. 30%; P ≤ .01). Conclusions: Wild-type patients are not anticoagulated in a sufficiently prompt manner after arthroplasty.

Original languageEnglish (US)
Pages (from-to)S145-S151
JournalJournal of Orthopaedics
Volume12
DOIs
StatePublished - Aug 1 2015
Externally publishedYes

Keywords

  • Arthroplasty
  • Deep venous thrombosis
  • Genetics
  • Thromboprophylaxis
  • Warfarin

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