The influence of different concentrations of volatile anesthetics on the threshold for cortical spreading depression in rats

Marleen Verhaegen, Michael M. Todd, David S. Warner

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

We studied the influence of halothane and isoflurane on the electrical threshold for triggering spreading depression (SD) in rats. While the N-methyl-d-aspartate (NMDA) antagonist ketamine dramatically increased the triggering threshold (and blocked propagation), neither volatile agent had any dose-related effect. High doses of both agents slightly slowed SD propagation rate. These results indicate that volatile agents in typical anesthetic doses can be used in studies of SD in rats, and also suggest that these agents have little effect on NMDA receptor-mediated neurotransmission.

Original languageEnglish (US)
Pages (from-to)153-155
Number of pages3
JournalBrain Research
Volume581
Issue number1
DOIs
StatePublished - May 22 1992

Keywords

  • Halothane
  • Isoflurane
  • N-Methyl-d-aspartate
  • Spreading depression
  • Volatile anesthetic

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