The Inflammatory Cytokine Profile Associated With Liver Damage Is Broader and Stronger in Patients With Chronic Hepatitis B Compared to Patients With Acute Hepatitis B

Alexandra Johnson Valiente; Kin Seng Liem; Kathleen B. Schwarz; Philip Rosenthal; Karen F. Murray; Douglas Mogul; Jeffery Teckman; Norberto Rodriguez-Baez; Sarah Jane Schwarzenberg; Jordan J. Feld; David K. Wong; Lia L. Lewis-Ximenez; Georg Lauer; Bettina E. Hansen; Simon C. Ling; Harry L.A. Janssen; Adam J. Gehring

doi:10.1093/infdis/jiab373

The Inflammatory Cytokine Profile Associated With Liver Damage Is Broader and Stronger in Patients With Chronic Hepatitis B Compared to Patients With Acute Hepatitis B

Alexandra Johnson Valiente
, Kin Seng Liem
, Kathleen B. Schwarz
, Philip Rosenthal
, Karen F. Murray
, Douglas Mogul
, Jeffery Teckman
, Norberto Rodriguez-Baez
, Sarah Jane Schwarzenberg
, Jordan J. Feld
, David K. Wong
, Lia L. Lewis-Ximenez
, Georg Lauer
, Bettina E. Hansen
, Simon C. Ling
, Harry L.A. Janssen
, Adam J. Gehring

Pediatric Gastroenterology, Hepatology & Nutrition

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Liver damage in hepatitis B is immune driven and correlates with inflammatory markers in patient serum. There is no comparison of these markers to determine if inflammatory profiles are distinct to different types of liver damage across patients at different stages of disease. We measured 25 inflammatory markers in patients with acute hepatitis B and chronic hepatitis B with hepatitis B e antigen seroconversion and chronic patients stopping nucleoside analogue therapy. Myeloid markers dominated the inflammatory profile in all stages of hepatitis B. More inflammatory markers were detectable in chronic patients, including elevated concentrations of cytotoxic effectors Fas ligand, TRAIL, and TNF-α.

Original language	English (US)
Pages (from-to)	470-475
Number of pages	6
Journal	Journal of Infectious Diseases
Volume	225
Issue number	3
DOIs	https://doi.org/10.1093/infdis/jiab373
State	Published - Feb 1 2022

Bibliographical note

Publisher Copyright:
© 2021 The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: [email protected].

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

HBV
biomarker
chemokines
cytokines
flare
hepatitis B
immune response
inflammation
plasma

Publisher link

10.1093/infdis/jiab373

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Johnson Valiente, A., Liem, K. S., Schwarz, K. B., Rosenthal, P., Murray, K. F., Mogul, D., Teckman, J., Rodriguez-Baez, N., Schwarzenberg, S. J., Feld, J. J., Wong, D. K., Lewis-Ximenez, L. L., Lauer, G., Hansen, B. E., Ling, S. C., Janssen, H. L. A., & Gehring, A. J. (2022). The Inflammatory Cytokine Profile Associated With Liver Damage Is Broader and Stronger in Patients With Chronic Hepatitis B Compared to Patients With Acute Hepatitis B. Journal of Infectious Diseases, 225(3), 470-475. https://doi.org/10.1093/infdis/jiab373

The Inflammatory Cytokine Profile Associated With Liver Damage Is Broader and Stronger in Patients With Chronic Hepatitis B Compared to Patients With Acute Hepatitis B. / Johnson Valiente, Alexandra; Liem, Kin Seng; Schwarz, Kathleen B. et al.
In: Journal of Infectious Diseases, Vol. 225, No. 3, 01.02.2022, p. 470-475.

Research output: Contribution to journal › Article › peer-review

Johnson Valiente, A, Liem, KS, Schwarz, KB, Rosenthal, P, Murray, KF, Mogul, D, Teckman, J, Rodriguez-Baez, N, Schwarzenberg, SJ, Feld, JJ, Wong, DK, Lewis-Ximenez, LL, Lauer, G, Hansen, BE, Ling, SC, Janssen, HLA & Gehring, AJ 2022, 'The Inflammatory Cytokine Profile Associated With Liver Damage Is Broader and Stronger in Patients With Chronic Hepatitis B Compared to Patients With Acute Hepatitis B', Journal of Infectious Diseases, vol. 225, no. 3, pp. 470-475. https://doi.org/10.1093/infdis/jiab373

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abstract = "Liver damage in hepatitis B is immune driven and correlates with inflammatory markers in patient serum. There is no comparison of these markers to determine if inflammatory profiles are distinct to different types of liver damage across patients at different stages of disease. We measured 25 inflammatory markers in patients with acute hepatitis B and chronic hepatitis B with hepatitis B e antigen seroconversion and chronic patients stopping nucleoside analogue therapy. Myeloid markers dominated the inflammatory profile in all stages of hepatitis B. More inflammatory markers were detectable in chronic patients, including elevated concentrations of cytotoxic effectors Fas ligand, TRAIL, and TNF-α.",

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AB - Liver damage in hepatitis B is immune driven and correlates with inflammatory markers in patient serum. There is no comparison of these markers to determine if inflammatory profiles are distinct to different types of liver damage across patients at different stages of disease. We measured 25 inflammatory markers in patients with acute hepatitis B and chronic hepatitis B with hepatitis B e antigen seroconversion and chronic patients stopping nucleoside analogue therapy. Myeloid markers dominated the inflammatory profile in all stages of hepatitis B. More inflammatory markers were detectable in chronic patients, including elevated concentrations of cytotoxic effectors Fas ligand, TRAIL, and TNF-α.

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The Inflammatory Cytokine Profile Associated With Liver Damage Is Broader and Stronger in Patients With Chronic Hepatitis B Compared to Patients With Acute Hepatitis B

Abstract

Bibliographical note

UN SDGs

Keywords

Publisher link

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