The induction of cytolytic T lymphocytes with syngeneic trinitrophenyl-coupled membranes

L. Sherman, M. F. Mescher, S. J. Burakoff

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2 Scopus citations

Abstract

Recently we have demonstrated the induction of allogeneic murine cytolytic T lymphocytes (CTL)3 using purified plasma membranes rather than intact cells as stimulatory agents. In this report we extend the use of such subcellular preparations to study the requirements for hapten-specific syngeneic CTL induction. Membranes prepared from trinitrophenyl (TNP) coupled syngeneic tumor cells retain the ability to stimulate both a primary and secondary CTL response. The CTL that are generated are restricted in their lysis to target cells bearing the same H-2 antigens as those present on the TNP-coupled stimulating membranes.

Original languageEnglish (US)
Pages (from-to)501-502
Number of pages2
JournalJournal of Immunology
Volume123
Issue number1
StatePublished - Dec 1 1979

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    Sherman, L., Mescher, M. F., & Burakoff, S. J. (1979). The induction of cytolytic T lymphocytes with syngeneic trinitrophenyl-coupled membranes. Journal of Immunology, 123(1), 501-502.