The induction of cytolytic T lymphocytes with purified plasma membranes

F. Lemonnier, M. Mescher, L. Sherman, S. Burakoff

Research output: Contribution to journalArticlepeer-review

53 Scopus citations

Abstract

Subcellular fractions were demonstrated to be effective in stimulating primary and secondary allogeneic CTL responses. 5' nucleotidase activity was used to assess purification of plasma membranes and stimulating activity was found to co-purify with the plasma membrane fraction of the cell. Electron micrographs of these purified plasma membranes showed the majority of the material to be in the form of vesicles of relatively heterogeneous size. The cytolytic T lymphocytes generated by incubation with purified plasma membranes demonstrated immunologic specificity.

Original languageEnglish (US)
Pages (from-to)1114-1120
Number of pages7
JournalJournal of Immunology
Volume120
Issue number4
StatePublished - Dec 1 1978

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