The increase in brain tryptophan caused by amphetamine-like drugs

Correlation with an increase in body temperature

David A. Brase, Horace H. Loh

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The effects of amphetamine, hyperthermia and increased serum unesterified fatty acids (UFA) were considered as having possible roles in the amphetamine-induced increase in brain tryptophan (Trp) levels. The change in brain Trp of male Sprague-Dawley rats 1 hour after the administration of various amphetamine-like drugs (50 μmoles/kg) correlated with the change in rectal temperature (r = 0.89) but not with the increase in serum UFA (r = 0.04). Also, increases in UFA did not correlate with increases in temperature (r = 0.01). The amphetamine-induced increase in brain Trp was not accompanied by significant changes in the levels of aromatic amino acids in serum. The amphetamine-induced increase in brain Trp also correlated with the increase in body temperature in six strains of mice (r = 0.93). No significant increases in serum UFA were observed in mice 1 hour after the administration of d1-amphetamine (50 μmoles/kg).

Original languageEnglish (US)
Pages (from-to)115-122
Number of pages8
JournalLife Sciences
Volume18
Issue number1
DOIs
StatePublished - Jan 1 1976

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Amphetamine
Body Temperature
Tryptophan
Brain
Fatty Acids
Pharmaceutical Preparations
Serum
Temperature
Aromatic Amino Acids
Sprague Dawley Rats
Rats
Fever

Cite this

The increase in brain tryptophan caused by amphetamine-like drugs : Correlation with an increase in body temperature. / Brase, David A.; Loh, Horace H.

In: Life Sciences, Vol. 18, No. 1, 01.01.1976, p. 115-122.

Research output: Contribution to journalArticle

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