The in vivo biology of the mitochondrial calcium uniporter

Julia C. Liu, Randi J. Parks, Jie Liu, Justin Stares, Ilsa I. Rovira, Elizabeth Murphy, Toren Finkel

Research output: Chapter in Book/Report/Conference proceedingChapter

13 Scopus citations

Abstract

The identification of the molecular composition of the mitochondrial calcium uniporter has allowed for the genetic manipulation of its components and the creation of various in vivo genetic models. Here, we review the initial attempts to modulate the expression of components of the calcium uniporter in a range of organisms from plants to mammals. This analysis has confirmed the strict requirement for the uniporter for in vivo mitochondrial calcium uptake and for maintaining mitochondrial calcium homeostasis. We further discuss the physiological effects following genetic manipulation of the uniporter on tissue bioenergetics and the threshold for cell death. Finally, we analyze the limited information regarding the role of various uniporter components in human disease.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages49-63
Number of pages15
DOIs
StatePublished - May 1 2017
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
Volume982
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Bibliographical note

Publisher Copyright:
© 2017, Springer International Publishing AG.

Keywords

  • MCU
  • Mitochondrial calcium
  • Model organisms
  • Mouse models
  • Uniporter

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