The impact of the Cancer Genome Atlas on lung cancer

Jeremy T.H. Chang, Yee Ming Lee, R. Stephanie Huang

Research output: Contribution to journalReview article

36 Scopus citations


The Cancer Genome Atlas (TCGA) has profiled more than 10,000 samples derived from 33 types of cancer to date, with the goal of improving our understanding of the molecular basis of cancer and advancing our ability to diagnose, treat, and prevent cancer. This review focuses on lung cancer as it is the leading cause of cancer-related mortality worldwide in both men and women. Particularly, non-small cell lung cancers (including lung adenocarcinoma and lung squamous cell carcinoma) were evaluated. Our goal was to demonstrate the impact of TCGA on lung cancer research under 4 themes: Diagnostic markers, disease progression markers, novel therapeutic targets, and novel tools. Examples are given related to DNA mutation, copy number variation, messenger RNA, and microRNA expression along with methylation profiling.

Original languageEnglish (US)
Pages (from-to)568-585
Number of pages18
JournalTranslational Research
Issue number6
StatePublished - Dec 1 2015
Externally publishedYes

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