The impact of symptomatic knee osteoarthritis on overall gait pattern deviations and its association with performance-based measures and patient-reported outcomes

Josefine E. Naili, Anna Clara Esbjörnsson, Maura D. Iversen, Michael H. Schwartz, Margareta Hedström, Charlotte K. Häger, Eva W. Broström

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Background Limited knowledge exists regarding the impact of symptomatic knee osteoarthritis (OA) on the overall gait pattern; and whether gait deviations are associated with performance-based measures (PBMs) and patient-reported outcomes (PROs). This cross-sectional study evaluated overall gait patterns in patients with knee OA using the Gait Deviation Index for kinematics (GDI) and kinetics (GDI-kinetic), and explored associations between gait deviations, PBMs, and PROs. Methods Forty patients with knee OA and 25 age and gender-matched controls underwent three-dimensional gait analysis. Participants performed the Timed Up and Go (TUG), Five Times Sit-to-Stand (5STS), and Single Limb Mini Squat (SLMS) tests and completed a disease-specific PRO. Associations between gait deviations, PBMs, and PROs were assessed by Pearson's correlation and multiple linear regression. Results Patients with OA demonstrated significantly lower GDI and GDI-kinetic scores of the OA and contralateral limbs compared to controls; with GDI-kinetic scores on the contralateral limb more impacted than the OA limb. On the contralateral limb, GDI-kinetic score significantly correlated with TUG (r = − 0.42) and 5STS (r = − 0.33), while on the OA limb with TUG (r = − 0.68), 5STS (r = − 0.38), SLMS (r = − 0.38), activities of daily living (r = 0.35) and Knee-related Quality of Life (r = 0.35). No significant associations existed between kinematic GDI scores, PBMs and PROs. Conclusion The overall gait pattern, as represented by GDI and GDI-kinetic scores, in patients with symptomatic knee OA is affected both on the painful OA limb and the contralateral limb. The GDI and GDI-kinetic scores provide different information regarding function that is not revealed by PBMs or PROs.

Original languageEnglish (US)
Pages (from-to)536-546
Number of pages11
JournalKnee
Volume24
Issue number3
DOIs
StatePublished - Jun 2017

Bibliographical note

Publisher Copyright:
© 2017 Elsevier B.V.

Keywords

  • Biomechanics
  • Function
  • Gait
  • Osteoarthritis
  • Outcome measures

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