The impact of race as a risk factor for symptom severity and age at diagnosis of uterine leiomyomata among affected sisters

Karen L. Huyck; Carolien I.M. Panhuysen; Karen T. Cuenco; Jingmei Zhang; Hilary Goldhammer; Emlyn S. Jones; Priya Somasundaram; Allison M. Lynch; Bernard L. Harlow; Hang Lee; Elizabeth A. Stewart; Cynthia C. Morton

doi:10.1016/j.ajog.2007.05.038

The impact of race as a risk factor for symptom severity and age at diagnosis of uterine leiomyomata among affected sisters

Karen L. Huyck, Carolien I.M. Panhuysen, Karen T. Cuenco, Jingmei Zhang, Hilary Goldhammer, Emlyn S. Jones, Priya Somasundaram, Allison M. Lynch, Bernard L. Harlow, Hang Lee, Elizabeth A. Stewart, Cynthia C. Morton

Epidemiology & Community Health

Research output: Contribution to journal › Article › peer-review

96 Scopus citations

Abstract

Objective: The objective of the study was to identify risk factors for uterine leiomyomata (UL) in a racially diverse population of women with a family history of UL, and to evaluate their contribution to disease severity and age at diagnosis. Study Design: We collected and analyzed epidemiologic data from 285 sister pairs diagnosed with UL. Risk factors for UL-related outcomes were compared among black (n = 73) and white (n = 212) sister pairs using univariate and multivariate regression models. Results: Black women reported an average age at diagnosis of 5.3 years younger (SE, 1.1; P < .001) and were more likely to report severe disease (odds ratio, 5.22; 95% confidence interval, 1.99-13.7, P < .001) than white women of similar socioeconomic status. Conclusion: Self-reported race is a significant factor in the severity of UL among women with a family history of UL. Differences in disease presentation between races likely reflect underlying genetic heterogeneity. The affected sister-pair study design can address both epidemiological and genetic hypotheses about UL.

Original language	English (US)
Pages (from-to)	168.e1-168.e9
Journal	American journal of obstetrics and gynecology
Volume	198
Issue number	2
DOIs	https://doi.org/10.1016/j.ajog.2007.05.038
State	Published - Feb 2008

Bibliographical note

Funding Information:
This work was supported in part by HD046226 (C.C.M.), an HHMI Predoctoral Fellowship in the Biological Sciences (K.L.H.), and DFHCC Biostatistics Core (P30 CA06516).

Keywords

family study
fibroids
racial differences
symptom severity
uterine leiomyomata

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10.1016/j.ajog.2007.05.038

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Huyck, K. L., Panhuysen, C. I. M., Cuenco, K. T., Zhang, J., Goldhammer, H., Jones, E. S., Somasundaram, P., Lynch, A. M., Harlow, B. L., Lee, H., Stewart, E. A., & Morton, C. C. (2008). The impact of race as a risk factor for symptom severity and age at diagnosis of uterine leiomyomata among affected sisters. American journal of obstetrics and gynecology, 198(2), 168.e1-168.e9. https://doi.org/10.1016/j.ajog.2007.05.038

Huyck, KL, Panhuysen, CIM, Cuenco, KT, Zhang, J, Goldhammer, H, Jones, ES, Somasundaram, P, Lynch, AM, Harlow, BL, Lee, H, Stewart, EA & Morton, CC 2008, 'The impact of race as a risk factor for symptom severity and age at diagnosis of uterine leiomyomata among affected sisters', American journal of obstetrics and gynecology, vol. 198, no. 2, pp. 168.e1-168.e9. https://doi.org/10.1016/j.ajog.2007.05.038

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abstract = "Objective: The objective of the study was to identify risk factors for uterine leiomyomata (UL) in a racially diverse population of women with a family history of UL, and to evaluate their contribution to disease severity and age at diagnosis. Study Design: We collected and analyzed epidemiologic data from 285 sister pairs diagnosed with UL. Risk factors for UL-related outcomes were compared among black (n = 73) and white (n = 212) sister pairs using univariate and multivariate regression models. Results: Black women reported an average age at diagnosis of 5.3 years younger (SE, 1.1; P < .001) and were more likely to report severe disease (odds ratio, 5.22; 95% confidence interval, 1.99-13.7, P < .001) than white women of similar socioeconomic status. Conclusion: Self-reported race is a significant factor in the severity of UL among women with a family history of UL. Differences in disease presentation between races likely reflect underlying genetic heterogeneity. The affected sister-pair study design can address both epidemiological and genetic hypotheses about UL.",

keywords = "family study, fibroids, racial differences, symptom severity, uterine leiomyomata",

author = "Huyck, {Karen L.} and Panhuysen, {Carolien I.M.} and Cuenco, {Karen T.} and Jingmei Zhang and Hilary Goldhammer and Jones, {Emlyn S.} and Priya Somasundaram and Lynch, {Allison M.} and Harlow, {Bernard L.} and Hang Lee and Stewart, {Elizabeth A.} and Morton, {Cynthia C.}",

note = "Funding Information: This work was supported in part by HD046226 (C.C.M.), an HHMI Predoctoral Fellowship in the Biological Sciences (K.L.H.), and DFHCC Biostatistics Core (P30 CA06516). ",

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doi = "10.1016/j.ajog.2007.05.038",

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AU - Huyck, Karen L.

AU - Panhuysen, Carolien I.M.

AU - Cuenco, Karen T.

AU - Zhang, Jingmei

AU - Goldhammer, Hilary

AU - Jones, Emlyn S.

AU - Somasundaram, Priya

AU - Lynch, Allison M.

AU - Harlow, Bernard L.

AU - Lee, Hang

AU - Stewart, Elizabeth A.

AU - Morton, Cynthia C.

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PY - 2008/2

Y1 - 2008/2

N2 - Objective: The objective of the study was to identify risk factors for uterine leiomyomata (UL) in a racially diverse population of women with a family history of UL, and to evaluate their contribution to disease severity and age at diagnosis. Study Design: We collected and analyzed epidemiologic data from 285 sister pairs diagnosed with UL. Risk factors for UL-related outcomes were compared among black (n = 73) and white (n = 212) sister pairs using univariate and multivariate regression models. Results: Black women reported an average age at diagnosis of 5.3 years younger (SE, 1.1; P < .001) and were more likely to report severe disease (odds ratio, 5.22; 95% confidence interval, 1.99-13.7, P < .001) than white women of similar socioeconomic status. Conclusion: Self-reported race is a significant factor in the severity of UL among women with a family history of UL. Differences in disease presentation between races likely reflect underlying genetic heterogeneity. The affected sister-pair study design can address both epidemiological and genetic hypotheses about UL.

AB - Objective: The objective of the study was to identify risk factors for uterine leiomyomata (UL) in a racially diverse population of women with a family history of UL, and to evaluate their contribution to disease severity and age at diagnosis. Study Design: We collected and analyzed epidemiologic data from 285 sister pairs diagnosed with UL. Risk factors for UL-related outcomes were compared among black (n = 73) and white (n = 212) sister pairs using univariate and multivariate regression models. Results: Black women reported an average age at diagnosis of 5.3 years younger (SE, 1.1; P < .001) and were more likely to report severe disease (odds ratio, 5.22; 95% confidence interval, 1.99-13.7, P < .001) than white women of similar socioeconomic status. Conclusion: Self-reported race is a significant factor in the severity of UL among women with a family history of UL. Differences in disease presentation between races likely reflect underlying genetic heterogeneity. The affected sister-pair study design can address both epidemiological and genetic hypotheses about UL.

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The impact of race as a risk factor for symptom severity and age at diagnosis of uterine leiomyomata among affected sisters

Abstract

Bibliographical note

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