The impact of pregnancy and childbirth on the metabolism of lamotrigine

P. B. Pennell; D. J. Newport; Z. N. Stowe; S. L. Helmers; J. Q. Montgomery; T. R. Henry

doi:10.1212/01.WNL.0000103286.47129.F8

The impact of pregnancy and childbirth on the metabolism of lamotrigine

P. B. Pennell, D. J. Newport, Z. N. Stowe, S. L. Helmers, J. Q. Montgomery, T. R. Henry

Research output: Contribution to journal › Article › peer-review

204 Scopus citations

Abstract

This study was performed to clarify alterations in lamotrigine (LTG) clearance during pregnancy and childbirth. Fourteen women on LTG monotherapy had LTG concentration samples obtained before conception and monthly. LTG apparent clearance, weight-adjusted relative clearance, and percentages of baseline clearance significantly differed between preconception baseline and each trimester and between trimesters. LTG clearance progressively increased until 32 weeks' gestational age, reaching a peak of >330% of baseline, and then began to decline.

Original language	English (US)
Pages (from-to)	292-295
Number of pages	4
Journal	Neurology
Volume	62
Issue number	2
DOIs	https://doi.org/10.1212/01.WNL.0000103286.47129.F8
State	Published - Jan 27 2004
Externally published	Yes

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AU - Stowe, Z. N.

AU - Helmers, S. L.

AU - Montgomery, J. Q.

AU - Henry, T. R.

PY - 2004/1/27

Y1 - 2004/1/27

N2 - This study was performed to clarify alterations in lamotrigine (LTG) clearance during pregnancy and childbirth. Fourteen women on LTG monotherapy had LTG concentration samples obtained before conception and monthly. LTG apparent clearance, weight-adjusted relative clearance, and percentages of baseline clearance significantly differed between preconception baseline and each trimester and between trimesters. LTG clearance progressively increased until 32 weeks' gestational age, reaching a peak of >330% of baseline, and then began to decline.

AB - This study was performed to clarify alterations in lamotrigine (LTG) clearance during pregnancy and childbirth. Fourteen women on LTG monotherapy had LTG concentration samples obtained before conception and monthly. LTG apparent clearance, weight-adjusted relative clearance, and percentages of baseline clearance significantly differed between preconception baseline and each trimester and between trimesters. LTG clearance progressively increased until 32 weeks' gestational age, reaching a peak of >330% of baseline, and then began to decline.

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The impact of pregnancy and childbirth on the metabolism of lamotrigine

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