The impact of child abuse on the neurobiology of self-processing in depressed adolescents

Maggie Engstrom, Guanmin Liu, Carmen Santana-Gonzalez, Jia Yuan Teoh, Madeline Harms, Kiry Koy, Karina Quevedo

Research output: Contribution to journalArticlepeer-review

Abstract

Child abuse is linked to lifetime psychopathology including abnormal self-processing. Given self-processing maturation in adolescence, we tested duration, presence, and abuse accumulation's impact upon self-processing neurobiology among depressed youth with (N = 54) and without an abuse history (N = 40). Youth evaluated positive and negative self-descriptors across four points of view in the scanner. Regression analyses showed that longer abuse duration (in days) was associated with lower activity in inferior temporal (e.g. insula, fusiform & parahippocampus), striatal, cerebellar and midbrain structures when processing negative self-descriptors with the least activity in youth exposed to 6+ abuse years. Abuse presence vs. absence was linked to higher neural activity. However, youth exposed to a single abuse instance to 3 years of abuse might drive that relative neural hyperactivity. Results support: 1) the toxic stress model of blunted overall neuro-reactivity underpinning emotion, sensorimotor gating, and social cognition during negative stimuli as an adaptation to pervasively toxic environments and 2) the differential impact of acute versus chronic stress upon neurophysiological indices. Finally, child abuse duration might impact these ancillary and higher socioemotional processes differently among depressed youth primarily for negative but not positive self-processing.

Original languageEnglish (US)
Article number100310
JournalNeurobiology of Stress
Volume14
DOIs
StatePublished - May 2021
Externally publishedYes

Bibliographical note

Funding Information:
This work was supported by grants awarded to KQ from the National Institute of Mental Health ( NIMH; MH092601 ), Brain & Behavior Research Foundation (NARSAD Young Investigator Award), and the U of M Clinical and Translational Science Institute for data collection and analysis and manuscript preparation. Funding sources were not involved in the design of this study, collection, analysis and interpretation of data or manuscript preparation.

Publisher Copyright:
© 2021

Keywords

  • Adolescence
  • Child abuse
  • Hippocampus
  • Neuroimaging
  • Self-processing

PubMed: MeSH publication types

  • Journal Article

Fingerprint Dive into the research topics of 'The impact of child abuse on the neurobiology of self-processing in depressed adolescents'. Together they form a unique fingerprint.

Cite this