The impact of animal age, bacterial coinfection, and isolate pathogenicity on the shedding of Porcine reproductive and respiratory syndrome virus in aerosols from experimentally infected pigs

Jenny G. Cho; Scott A. Dee; John Deen; Carlos Trincado; Eduardo Fano; Yin Jiang; Kay Faaberg; Michael P Murtaugh; Alonso Guedes; Jim Collins; Han Soo Joo

The impact of animal age, bacterial coinfection, and isolate pathogenicity on the shedding of Porcine reproductive and respiratory syndrome virus in aerosols from experimentally infected pigs

Jenny G. Cho, Scott A. Dee, John Deen, Carlos Trincado, Eduardo Fano, Yin Jiang, Kay Faaberg, Michael P Murtaugh, Alonso Guedes, Jim Collins, Han Soo Joo

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Abstract

The objective of this study was to evaluate the role of different variables (animal age, bacterial coinfection, and isolate pathogenicity) on the shedding of Porcine reproductive and respiratory syndrome virus (PRRSV) in aerosols. Animals were grouped according to age (2 versus 6 mo) and inoculated with a PRRSV isolate of either low (MN-30100) or high (MN-184) pathogenicity. Selected animals in each group were also inoculated with Mycoplasma hyopneumoniae. The pigs were anesthetized and aerosol samples (1000 breaths/sample) collected on alternating days from 1 to 21 after PRRSV inoculation. The results indicated that animal age (P = 0.09), M. hyopneumoniae coinfection (P = 0.09), and PRRSV isolate pathogenicity (P = 0.15) did not significantly influence the concentration of PRRSV in aerosols. However, inoculation with the PRRSV MN-184 isolate significantly increased the probability of aerosol shedding (P = 0.00005; odds ratio = 3.22). Therefore, the shedding of PRRSV in aerosols may be isolate-dependent.

Original language	English (US)
Pages (from-to)	297-301
Number of pages	5
Journal	Canadian Journal of Veterinary Research
Volume	70
Issue number	4
State	Published - Oct 2006

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Cho, J. G., Dee, S. A., Deen, J., Trincado, C., Fano, E., Jiang, Y., Faaberg, K., Murtaugh, M. P., Guedes, A., Collins, J., & Joo, H. S. (2006). The impact of animal age, bacterial coinfection, and isolate pathogenicity on the shedding of Porcine reproductive and respiratory syndrome virus in aerosols from experimentally infected pigs. Canadian Journal of Veterinary Research, 70(4), 297-301.

The impact of animal age, bacterial coinfection, and isolate pathogenicity on the shedding of Porcine reproductive and respiratory syndrome virus in aerosols from experimentally infected pigs. / Cho, Jenny G.; Dee, Scott A.; Deen, John et al.
In: Canadian Journal of Veterinary Research, Vol. 70, No. 4, 10.2006, p. 297-301.

Research output: Contribution to journal › Article › peer-review

Cho, JG, Dee, SA, Deen, J, Trincado, C, Fano, E, Jiang, Y, Faaberg, K, Murtaugh, MP, Guedes, A , Collins, J & Joo, HS 2006, 'The impact of animal age, bacterial coinfection, and isolate pathogenicity on the shedding of Porcine reproductive and respiratory syndrome virus in aerosols from experimentally infected pigs', Canadian Journal of Veterinary Research, vol. 70, no. 4, pp. 297-301.

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abstract = "The objective of this study was to evaluate the role of different variables (animal age, bacterial coinfection, and isolate pathogenicity) on the shedding of Porcine reproductive and respiratory syndrome virus (PRRSV) in aerosols. Animals were grouped according to age (2 versus 6 mo) and inoculated with a PRRSV isolate of either low (MN-30100) or high (MN-184) pathogenicity. Selected animals in each group were also inoculated with Mycoplasma hyopneumoniae. The pigs were anesthetized and aerosol samples (1000 breaths/sample) collected on alternating days from 1 to 21 after PRRSV inoculation. The results indicated that animal age (P = 0.09), M. hyopneumoniae coinfection (P = 0.09), and PRRSV isolate pathogenicity (P = 0.15) did not significantly influence the concentration of PRRSV in aerosols. However, inoculation with the PRRSV MN-184 isolate significantly increased the probability of aerosol shedding (P = 0.00005; odds ratio = 3.22). Therefore, the shedding of PRRSV in aerosols may be isolate-dependent.",

author = "Cho, {Jenny G.} and Dee, {Scott A.} and John Deen and Carlos Trincado and Eduardo Fano and Yin Jiang and Kay Faaberg and Murtaugh, {Michael P} and Alonso Guedes and Jim Collins and Joo, {Han Soo}",

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AU - Trincado, Carlos

AU - Fano, Eduardo

AU - Jiang, Yin

AU - Faaberg, Kay

AU - Murtaugh, Michael P

AU - Guedes, Alonso

AU - Collins, Jim

AU - Joo, Han Soo

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The impact of animal age, bacterial coinfection, and isolate pathogenicity on the shedding of Porcine reproductive and respiratory syndrome virus in aerosols from experimentally infected pigs

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