The Impact of Alemtuzumab and Basiliximab Induction on Patient Survival and Time to Bronchiolitis Obliterans Syndrome in Double Lung Transplantation Recipients

Y. Furuya, S. N. Jayarajan, S. Taghavi, F. C. Cordova, N. Patel, A. Shiose, E. Leotta, G. J. Criner, T. S. Guy, G. H. Wheatley, L. R. Kaiser, Y. Toyoda

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21 Scopus citations

Abstract

We examined the effect of alemtuzumab and basiliximab induction therapy on patient survival and freedom from bronchiolitis obliterans syndrome (BOS) in double lung transplantation. The United Network for Organ Sharing database was reviewed for adult double lung transplant recipients from 2006 to 2013. The primary outcome was risk-adjusted all-cause mortality. Secondary outcomes included time to BOS. There were 6117 patients were identified, of whom 738 received alemtuzumab, 2804 received basiliximab, and 2575 received no induction. Alemtuzumab recipients had higher lung allocation scores compared with basiliximab and no-induction recipients (41.4 versus 37.9 versus 40.7, p < 0.001) and were more likely to require mechanical ventilation before to transplantation (21.7% versus 6.5% versus 6.2%, p < 0.001). Median survival was longer for alemtuzumab and basiliximab recipients compared with patients who received no induction (2321 versus 2352 versus 1967 days, p = 0.001). Alemtuzumab (hazard ratio 0.80, 95% confidence interval 0.67–0.95, p = 0.009) and basiliximab induction (0.88, 0.80–0.98, p = 0.015) were independently associated with survival on multivariate analysis. At 5 years, alemtuzumab recipients had a lower incidence of BOS (22.7% versus 55.4 versus 55.9%), and its use was independently associated with lower risk of developing BOS on multivariate analysis. While both induction therapies were associated with improved survival, patients who received alemtuzumab had greater median freedom from BOS.

Original languageEnglish (US)
Pages (from-to)2334-2341
Number of pages8
JournalAmerican Journal of Transplantation
Volume16
Issue number8
DOIs
StatePublished - Aug 1 2016

Keywords

  • bronchiolitis obliterans (BOS)
  • clinical research/practice
  • fusion proteins and monoclonal antibodies: alemtuzumab
  • fusion proteins and monoclonal antibodies: basiliximab/daclizumab
  • health services and outcomes research
  • immunosuppressant
  • immunosuppression/immune modulation
  • immunosuppressive regimens
  • induction
  • lung (allograft) function/dysfunction
  • lung transplantation/pulmonology

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    Furuya, Y., Jayarajan, S. N., Taghavi, S., Cordova, F. C., Patel, N., Shiose, A., Leotta, E., Criner, G. J., Guy, T. S., Wheatley, G. H., Kaiser, L. R., & Toyoda, Y. (2016). The Impact of Alemtuzumab and Basiliximab Induction on Patient Survival and Time to Bronchiolitis Obliterans Syndrome in Double Lung Transplantation Recipients. American Journal of Transplantation, 16(8), 2334-2341. https://doi.org/10.1111/ajt.13739