The immunosuppressive side of PDT

Pawel Mroz, Michael R. Hamblin

Research output: Contribution to journalReview articlepeer-review

66 Scopus citations


Photodynamic therapy (PDT) is a promising novel therapeutic procedure for the management of a variety of solid tumors and many non-malignant diseases. PDT has been described as having a significant effect on the immune system, which may be either immunostimulatory or, in some circumstances, immunosuppressive. The immunosuppressive effects of PDT have nearly all been concerned with the suppression of the contact hypersensitivity reaction in mice. Here, we review the immunosuppressive aspects of PDT treatment and discuss some additional mechanisms that may be involved.

Original languageEnglish (US)
Pages (from-to)751-758
Number of pages8
JournalPhotochemical and Photobiological Sciences
Issue number5
StatePublished - May 2011


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