The Immune Landscape of Visceral Adipose Tissue During Obesity and Aging

Saad Khan; Yi Tao Chan; Xavier S Revelo; Daniel A Winer

doi:10.3389/fendo.2020.00267

The Immune Landscape of Visceral Adipose Tissue During Obesity and Aging

Saad Khan
, Yi Tao Chan
, Xavier S Revelo
, Daniel A Winer

Research output: Contribution to journal › Review article › peer-review

96 Scopus citations

Abstract

Obesity and aging represent major health burdens to the global adult population. Both conditions promote the development of associated metabolic diseases such as insulin resistance. The visceral adipose tissue (VAT) is a site that becomes dysfunctional during obesity and aging, and plays a significant role during their pathophysiology. The changes in obese and aging VAT are now recognized to be partly driven by a chronic local inflammatory state, characterized by immune cells that typically adopt an inflammatory phenotype during metabolic disease. Here, we summarize the current knowledge on the immune cell landscape of the VAT during lean, obese, and aged conditions, highlighting their similarities and differences. We also briefly discuss possible linked mechanisms that fuel obesity- and age-associated VAT dysfunction.

Original language	English (US)
Article number	267
Pages (from-to)	267
Journal	Frontiers in Endocrinology
Volume	11
DOIs	https://doi.org/10.3389/fendo.2020.00267
State	Published - May 15 2020

Bibliographical note

Funding Information:
Funding. SK was a recipient of the Queen Elizabeth II Graduate Scholarship in Science and Technology (QEII-GSST)/Aventis Pasteur, and the Banting & Best Centre (BBDC)-Novo Nordisk Studentship. XR was funded by a National Institute of Health (NIH) Research Project Grant 1R01DK122056 (XR). DW was funded by a Canadian Institutes of Health Research (CIHR) New Investigator Foundation Grant FDN-148385 (DW) and a Canadian Liver Foundation operating grant (2017). DW holds an Ontario Ministry of Innovation Early Researcher Award.

Publisher Copyright:
© Copyright © 2020 Khan, Chan, Revelo and Winer.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

aging
diabetes
immunology
immunometabolism
insulin resistance
metabolism
obesity
visceral adipose tissue

PubMed: MeSH publication types

Review
Research Support, Non-U.S. Gov't
Journal Article
Research Support, N.I.H., Extramural

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10.3389/fendo.2020.00267

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abstract = "Obesity and aging represent major health burdens to the global adult population. Both conditions promote the development of associated metabolic diseases such as insulin resistance. The visceral adipose tissue (VAT) is a site that becomes dysfunctional during obesity and aging, and plays a significant role during their pathophysiology. The changes in obese and aging VAT are now recognized to be partly driven by a chronic local inflammatory state, characterized by immune cells that typically adopt an inflammatory phenotype during metabolic disease. Here, we summarize the current knowledge on the immune cell landscape of the VAT during lean, obese, and aged conditions, highlighting their similarities and differences. We also briefly discuss possible linked mechanisms that fuel obesity- and age-associated VAT dysfunction.",

keywords = "aging, diabetes, immunology, immunometabolism, insulin resistance, metabolism, obesity, visceral adipose tissue",

author = "Saad Khan and Chan, \{Yi Tao\} and Revelo, \{Xavier S\} and Winer, \{Daniel A\}",

note = "Funding Information: Funding. SK was a recipient of the Queen Elizabeth II Graduate Scholarship in Science and Technology (QEII-GSST)/Aventis Pasteur, and the Banting \& Best Centre (BBDC)-Novo Nordisk Studentship. XR was funded by a National Institute of Health (NIH) Research Project Grant 1R01DK122056 (XR). DW was funded by a Canadian Institutes of Health Research (CIHR) New Investigator Foundation Grant FDN-148385 (DW) and a Canadian Liver Foundation operating grant (2017). DW holds an Ontario Ministry of Innovation Early Researcher Award. Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2020 Khan, Chan, Revelo and Winer.",

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language = "English (US)",

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AU - Khan, Saad

AU - Chan, Yi Tao

AU - Revelo, Xavier S

AU - Winer, Daniel A

N1 - Funding Information: Funding. SK was a recipient of the Queen Elizabeth II Graduate Scholarship in Science and Technology (QEII-GSST)/Aventis Pasteur, and the Banting & Best Centre (BBDC)-Novo Nordisk Studentship. XR was funded by a National Institute of Health (NIH) Research Project Grant 1R01DK122056 (XR). DW was funded by a Canadian Institutes of Health Research (CIHR) New Investigator Foundation Grant FDN-148385 (DW) and a Canadian Liver Foundation operating grant (2017). DW holds an Ontario Ministry of Innovation Early Researcher Award. Publisher Copyright: © Copyright © 2020 Khan, Chan, Revelo and Winer.

PY - 2020/5/15

Y1 - 2020/5/15

N2 - Obesity and aging represent major health burdens to the global adult population. Both conditions promote the development of associated metabolic diseases such as insulin resistance. The visceral adipose tissue (VAT) is a site that becomes dysfunctional during obesity and aging, and plays a significant role during their pathophysiology. The changes in obese and aging VAT are now recognized to be partly driven by a chronic local inflammatory state, characterized by immune cells that typically adopt an inflammatory phenotype during metabolic disease. Here, we summarize the current knowledge on the immune cell landscape of the VAT during lean, obese, and aged conditions, highlighting their similarities and differences. We also briefly discuss possible linked mechanisms that fuel obesity- and age-associated VAT dysfunction.

AB - Obesity and aging represent major health burdens to the global adult population. Both conditions promote the development of associated metabolic diseases such as insulin resistance. The visceral adipose tissue (VAT) is a site that becomes dysfunctional during obesity and aging, and plays a significant role during their pathophysiology. The changes in obese and aging VAT are now recognized to be partly driven by a chronic local inflammatory state, characterized by immune cells that typically adopt an inflammatory phenotype during metabolic disease. Here, we summarize the current knowledge on the immune cell landscape of the VAT during lean, obese, and aged conditions, highlighting their similarities and differences. We also briefly discuss possible linked mechanisms that fuel obesity- and age-associated VAT dysfunction.

KW - aging

KW - diabetes

KW - immunology

KW - immunometabolism

KW - insulin resistance

KW - metabolism

KW - obesity

KW - visceral adipose tissue

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UR - https://www.scopus.com/pages/publications/85085601056#tab=citedBy

U2 - 10.3389/fendo.2020.00267

DO - 10.3389/fendo.2020.00267

M3 - Review article

C2 - 32499756

SN - 1664-2392

VL - 11

SP - 267

JO - Frontiers in Endocrinology

JF - Frontiers in Endocrinology

M1 - 267

ER -

The Immune Landscape of Visceral Adipose Tissue During Obesity and Aging

Abstract

Bibliographical note

UN SDGs

Keywords

PubMed: MeSH publication types

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