The IGF system and breast cancer

Research output: Contribution to journalArticlepeer-review

282 Scopus citations


The IGF system components have been implicated in breast cancer progression. IGF-I and IGF-II are mitogenic and anti-apoptotic peptides that influence the proliferation of various cell types including normal and transformed breast epithelial cells. The IGF system is a key growth regulatory pathway in breast cancer. As various components of the IGF system have been directly or indirectly implicated in breast cancer, it is essential to gain a better understanding of these in order to develop more specific therapeutic strategies for treating breast cancer.

Original languageEnglish (US)
Pages (from-to)197-209
Number of pages13
JournalEndocrine-related cancer
Issue number3
StatePublished - Oct 20 2001


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