The Identification of JAK2 Tyrosine Kinase as a Signaling Molecule for Growth Hormone

Christin Carter-su, Lawrence S. Argetsinger, George S. Campbell, Xueyan Wang, James Ihle, Bruce Witthuhn

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

The intracellular pathways by which the binding of growth hormone (GH) to its receptor elicits its diverse effects have eluded investigators for many years. Studies showing that GH rapidly stimulates tyrosyl phosphorylation of cellular proteins, and that tyrosine kinase activity co-purifies with GH-GH receptor complexes, led us to hypothesize that activation by GH of a receptor-associated tyrosine kinase is an important early, and perhaps, initiating step in signal transduction by GH. Here, we review the work identifying JAK2 as a GH receptor-associated tyrosine kinase that is rapidly activated by ligand binding.

Original languageEnglish (US)
Pages (from-to)210-215
Number of pages6
JournalProceedings of the Society for Experimental Biology and Medicine
Volume206
Issue number3
DOIs
StatePublished - Jul 1994

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