The hypothalamic-pituitary-adrenal axis and viral infection

Michael Bailey, Harald Engler, John Hunzeker, John F. Sheridan

Research output: Contribution to journalReview articlepeer-review

86 Scopus citations


The hypothalamic-pituitary-adrenal (HPA) axis plays an important immunomodulatory role during viral infection. Activation of the HPA axis ultimately leads to elevated plasma levels of glucocorticoid (GC) hormones with the ability to mediate adaptive behavioral, metabolic, cardiovascular and immune system effects. In this review, we focus on the modulation of anti-viral immunity and viral pathogenesis by the HPA axis.

Original languageEnglish (US)
Pages (from-to)141-157
Number of pages17
JournalViral Immunology
Issue number2
StatePublished - 2003


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