The hydrophobic- Subtraction model of reversed-phase column selectivity

Lloyd R. Snyder, John W. Dolan, Daniel H. Marchand, Peter W. Carr

Research output: Contribution to journalArticlepeer-review

37 Scopus citations
Original languageEnglish (US)
Pages (from-to)297-376
Number of pages80
JournalAdvances in Chromatography
Volume50
StatePublished - 2015

Bibliographical note

Funding Information:
It is appropriate to acknowledge the help of a number of different people and institutions, in the completion of the present 6-year study. First, 24 active participants in this project can be identified as the co-authors of eleven previous papers [4,5,10–12,30–33,72,75] . Second, almost every major column company has donated columns to this project for the measurement of values of H , S * , etc.; their names are provided in Table 13 . Third, a major part of the funding required for the work described in papers [4,5,10–12,30–33,72,75] was provided by Small Business Innovative Research (SBIR) grants from the National Institutes of Health. Fourth, we are much indebted to the Product Quality Research Institute and its membership for carrying out inter-laboratory comparisons of our column characterization procedure [30] , for examples of its application to practical assay procedures [72] , and for ongoing studies involving the selection of columns of greatly differing selectivity for use in orthogonal separations. Fifth, the coordination of early studies among different groups was supported by Nan Wilson of BASi, while Jonathan Gilroy of BASi has filled a similar critical role in later studies. Finally, we are indebted to Uwe Neue (Waters Corp.), Colin Poole (Wayne State University), Daniel Marchand and Ken Croes (University of Wisconsin, River Falls), and David McCalley (University of the West of England) for their help with the present paper.

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