The Human Connectome Project's neuroimaging approach

Matthew F. Glasser, Stephen M. Smith, Daniel S. Marcus, Jesper L R Andersson, Edward J. Auerbach, Timothy E J Behrens, Timothy S. Coalson, Michael P. Harms, Mark Jenkinson, Steen Moeller, Emma C. Robinson, Stamatios N. Sotiropoulos, Junqian Xu, Essa Yacoub, Kamil Ugurbil, David C. Van Essen

Research output: Contribution to journalReview articlepeer-review

482 Scopus citations


Noninvasive human neuroimaging has yielded many discoveries about the brain. Numerous methodological advances have also occurred, though inertia has slowed their adoption. This paper presents an integrated approach to data acquisition, analysis and sharing that builds upon recent advances, particularly from the Human Connectome Project (HCP). The 'HCP-style' paradigm has seven core tenets: (i) collect multimodal imaging data from many subjects; (ii) acquire data at high spatial and temporal resolution; (iii) preprocess data to minimize distortions, blurring and temporal artifacts; (iv) represent data using the natural geometry of cortical and subcortical structures; (v) accurately align corresponding brain areas across subjects and studies; (vi) analyze data using neurobiologically accurate brain parcellations; and (vii) share published data via user-friendly databases. We illustrate the HCP-style paradigm using existing HCP data sets and provide guidance for future research. Widespread adoption of this paradigm should accelerate progress in understanding the brain in health and disease.

Original languageEnglish (US)
Pages (from-to)1175-1187
Number of pages13
JournalNature neuroscience
Issue number9
StatePublished - Sep 1 2016

Bibliographical note

Funding Information:
Supported in part by the Human Connectome Project, WU-Minn-Ox Consortium (1U54MH091657) funded by the 16 NIH Institutes and Centers that support the NIH Blueprint for Neuroscience Research; the McDonnell Center for Systems Neuroscience at Washington University; and NIH F30 MH097312 (M.F.G.), RO1 MH-60974 (D.C.V.E.), P41 EB015894 (NIBIB; K.U.), Wellcome Trust 098369/Z/12/Z (S.M.S., J.L.R.A., T.E.J.B., M.J., E.C.R., S.N.S.), 5R01EB009352 (D.S.M.), 5P30NS048056 (D.S.M.) and 5R24MH108315 (D.S.M.).

Publisher Copyright:
© 2016 Nature America, Inc.


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