The HERITAGE family study: Quality assurance and quality control

Jacques Gagnon; Michael A. Province; Claude Bouchard; Arthur S. Leon; James S. Skinner; Jack H. Wilmore; D. C. Rao

doi:10.1016/S1047-2797(96)00068-3

The HERITAGE family study: Quality assurance and quality control

Jacques Gagnon, Michael A. Province, Claude Bouchard, Arthur S. Leon, James S. Skinner, Jack H. Wilmore, D. C. Rao

Kinesiology

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

The HERITAGE (HEalth, RIsk factors, exercise Training And GEnetics) Family Study is the first multicenter family clinical trial of its kind. Conducted by a consortium of five universities in the United States and Canada, the study has as its primary goal to document the role of the genotype in the cardiovascular, metabolic, and hormonal responses to aerobic exercise. A comprehensive protocol was implemented at four Clinical Centers (CC) for the generation of data on sedentary subjects. This group included 450 caucasians from 90 nuclear families (father, mother, three children) and 200 black subjects from 40 to 100 family units over a 5-year period. The entire family was tested before and after a 20-week exercise training program. The fifth participating center, the Data Coordinating Center (DCC), is responsible for data management and data analysis. A Consortium Coordinating Center (CCC) responsible for the overall coordination and direction of the study was established at the Quebec CC. Quality assurance and quality control are jointly coordinated by the CCC and the DCC. A multicenter study of this magnitude requires careful standardization of all procedures and constant monitoring of quality control at all levels operation. This report describes the quality assurance and quality control measures implemented in the HERITAGE Family Study, including some examples with real data.

Original language	English (US)
Pages (from-to)	520-529
Number of pages	10
Journal	Annals of epidemiology
Volume	6
Issue number	6
DOIs	https://doi.org/10.1016/S1047-2797(96)00068-3
State	Published - Nov 1996

Bibliographical note

Funding Information:
The HERITAGE Family Study is supported hy the National Heart, Lung and Blood institute through the following grants: HI.45670 (C. Rouchatd); HL47323 (A. S. Leon); HL47317 (D. C. Rae); HL47327 (J. S. Skinner), and HL47321 (J. H. Wilmote). The study IS also supported m part hy grant MOl-RR@O-400 from the National Center for Research Sources to the University of Minnesota Clinical Research Cenrer. Thanks are expressed to all the Co-Principal Investigators, Cure 1 .ahorato~ Directors, Investigators, Co-investigators. Local Project Coordinators, rosearch assts-rants, laboratory technicians, and secretaries who arc contrihurmg to the study. Finally, the entire HERITAGE consortium is v<xry thankful to those hard-working participating families whose involvemrnr demonstrates the feasibility this study

Keywords

Exercise training
cardiovascular disease
diabetes
family study
genetics
quality control
sedentary lifestyle

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "The HERITAGE family study: Quality assurance and quality control",

abstract = "The HERITAGE (HEalth, RIsk factors, exercise Training And GEnetics) Family Study is the first multicenter family clinical trial of its kind. Conducted by a consortium of five universities in the United States and Canada, the study has as its primary goal to document the role of the genotype in the cardiovascular, metabolic, and hormonal responses to aerobic exercise. A comprehensive protocol was implemented at four Clinical Centers (CC) for the generation of data on sedentary subjects. This group included 450 caucasians from 90 nuclear families (father, mother, three children) and 200 black subjects from 40 to 100 family units over a 5-year period. The entire family was tested before and after a 20-week exercise training program. The fifth participating center, the Data Coordinating Center (DCC), is responsible for data management and data analysis. A Consortium Coordinating Center (CCC) responsible for the overall coordination and direction of the study was established at the Quebec CC. Quality assurance and quality control are jointly coordinated by the CCC and the DCC. A multicenter study of this magnitude requires careful standardization of all procedures and constant monitoring of quality control at all levels operation. This report describes the quality assurance and quality control measures implemented in the HERITAGE Family Study, including some examples with real data.",

keywords = "Exercise training, cardiovascular disease, diabetes, family study, genetics, quality control, sedentary lifestyle",

author = "Jacques Gagnon and Province, {Michael A.} and Claude Bouchard and Leon, {Arthur S.} and Skinner, {James S.} and Wilmore, {Jack H.} and Rao, {D. C.}",

note = "Funding Information: The HERITAGE Family Study is supported hy the National Heart, Lung and Blood institute through the following grants: HI.45670 (C. Rouchatd); HL47323 (A. S. Leon); HL47317 (D. C. Rae); HL47327 (J. S. Skinner), and HL47321 (J. H. Wilmote). The study IS also supported m part hy grant MOl-RR@O-400 from the National Center for Research Sources to the University of Minnesota Clinical Research Cenrer. Thanks are expressed to all the Co-Principal Investigators, Cure 1 .ahorato~ Directors, Investigators, Co-investigators. Local Project Coordinators, rosearch assts-rants, laboratory technicians, and secretaries who arc contrihurmg to the study. Finally, the entire HERITAGE consortium is v<xry thankful to those hard-working participating families whose involvemrnr demonstrates the feasibility this study",

year = "1996",

month = nov,

doi = "10.1016/S1047-2797(96)00068-3",

language = "English (US)",

volume = "6",

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journal = "Annals of Epidemiology",

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T2 - Quality assurance and quality control

AU - Gagnon, Jacques

AU - Province, Michael A.

AU - Bouchard, Claude

AU - Leon, Arthur S.

AU - Skinner, James S.

AU - Wilmore, Jack H.

AU - Rao, D. C.

N1 - Funding Information: The HERITAGE Family Study is supported hy the National Heart, Lung and Blood institute through the following grants: HI.45670 (C. Rouchatd); HL47323 (A. S. Leon); HL47317 (D. C. Rae); HL47327 (J. S. Skinner), and HL47321 (J. H. Wilmote). The study IS also supported m part hy grant MOl-RR@O-400 from the National Center for Research Sources to the University of Minnesota Clinical Research Cenrer. Thanks are expressed to all the Co-Principal Investigators, Cure 1 .ahorato~ Directors, Investigators, Co-investigators. Local Project Coordinators, rosearch assts-rants, laboratory technicians, and secretaries who arc contrihurmg to the study. Finally, the entire HERITAGE consortium is v<xry thankful to those hard-working participating families whose involvemrnr demonstrates the feasibility this study

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N2 - The HERITAGE (HEalth, RIsk factors, exercise Training And GEnetics) Family Study is the first multicenter family clinical trial of its kind. Conducted by a consortium of five universities in the United States and Canada, the study has as its primary goal to document the role of the genotype in the cardiovascular, metabolic, and hormonal responses to aerobic exercise. A comprehensive protocol was implemented at four Clinical Centers (CC) for the generation of data on sedentary subjects. This group included 450 caucasians from 90 nuclear families (father, mother, three children) and 200 black subjects from 40 to 100 family units over a 5-year period. The entire family was tested before and after a 20-week exercise training program. The fifth participating center, the Data Coordinating Center (DCC), is responsible for data management and data analysis. A Consortium Coordinating Center (CCC) responsible for the overall coordination and direction of the study was established at the Quebec CC. Quality assurance and quality control are jointly coordinated by the CCC and the DCC. A multicenter study of this magnitude requires careful standardization of all procedures and constant monitoring of quality control at all levels operation. This report describes the quality assurance and quality control measures implemented in the HERITAGE Family Study, including some examples with real data.

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KW - Exercise training

KW - cardiovascular disease

KW - diabetes

KW - family study

KW - genetics

KW - quality control

KW - sedentary lifestyle

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ER -

The HERITAGE family study: Quality assurance and quality control

Abstract

Bibliographical note

Keywords

UN SDGs

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