The hemodynamic response in children with Simplex Autism

Eric Feczko, Francis M. Miezin, John N. Constantino, Bradley L. Schlaggar, Steven E. Petersen, John R. Pruett

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Background: Numerous functional magnetic resonance imaging (fMRI) studies of the brain-bases of autism have demonstrated altered cortical responses in subjects with autism, relative to typical subjects, during a variety of tasks. These differences may reflect altered neuronal responses or altered hemodynamic response. This study searches for evidence of hemodynamic response differences by using a simple visual stimulus and elementary motor actions, which should elicit similar neuronal responses in patients and controls. Methods: We acquired fMRI data from two groups of 16 children, a typical group and a group with Simplex Autism, during a simple visuomotor paradigm previously used to assess this question in other cross-group comparisons. A general linear model estimated the blood-oxygen-level-dependent (BOLD) signal time course, and repeated-measures analysis of variance tested for potential cross-group differences in the BOLD signal. Results: The hemodynamic response in Simplex Autism is similar to that found in typical children. Although the sample size was small for a secondary analysis, medication appeared to have no effect on the hemodynamic response within the Simplex Autism group. Conclusions: When fMRI studies show BOLD response differences between autistic and typical subjects, these results likely reflect between-group differences in neural activity and not an altered hemodynamic response.

Original languageEnglish (US)
Pages (from-to)396-408
Number of pages13
JournalDevelopmental Cognitive Neuroscience
Volume2
Issue number4
DOIs
StatePublished - Oct 2012
Externally publishedYes

Keywords

  • Autism spectrum disorders
  • Event-related
  • Functional magnetic resonance imaging
  • Medication effects
  • Neurovascular coupling
  • Visuomotor

Fingerprint Dive into the research topics of 'The hemodynamic response in children with Simplex Autism'. Together they form a unique fingerprint.

  • Cite this

    Feczko, E., Miezin, F. M., Constantino, J. N., Schlaggar, B. L., Petersen, S. E., & Pruett, J. R. (2012). The hemodynamic response in children with Simplex Autism. Developmental Cognitive Neuroscience, 2(4), 396-408. https://doi.org/10.1016/j.dcn.2012.06.001