The heavy chain of human histocompatibility antigen HLA-B7 contains an immunoglobulin-like region

Harry T. Orr, Doron Lancet, Richard J. Robb, José A.Lopez De Castro, Jack L. Strominger

Research output: Contribution to journalArticle

92 Citations (Scopus)

Abstract

The 88-residue fragment (ac-2) containing the second disulphide loop from HLA-B7 heavy chain is shown to have statistically significant homology with Ig constant domains, including both matches at invariant positions and conservative substitutions of structurally important residues. Thus, both the light chain (β2m) and a segment of the heavy chain of HLA antigens may be structurally and evolutionarily related to immunoglobulins.

Original languageEnglish (US)
Pages (from-to)266-270
Number of pages5
JournalNature
Volume282
Issue number5736
DOIs
StatePublished - Dec 1 1979

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HLA-B7 Antigen
Histocompatibility Antigens
HLA Antigens
Disulfides
Immunoglobulins
Light
Immunoglobulin Domains

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Orr, H. T., Lancet, D., Robb, R. J., De Castro, J. A. L., & Strominger, J. L. (1979). The heavy chain of human histocompatibility antigen HLA-B7 contains an immunoglobulin-like region. Nature, 282(5736), 266-270. https://doi.org/10.1038/282266a0

The heavy chain of human histocompatibility antigen HLA-B7 contains an immunoglobulin-like region. / Orr, Harry T.; Lancet, Doron; Robb, Richard J.; De Castro, José A.Lopez; Strominger, Jack L.

In: Nature, Vol. 282, No. 5736, 01.12.1979, p. 266-270.

Research output: Contribution to journalArticle

Orr, HT, Lancet, D, Robb, RJ, De Castro, JAL & Strominger, JL 1979, 'The heavy chain of human histocompatibility antigen HLA-B7 contains an immunoglobulin-like region', Nature, vol. 282, no. 5736, pp. 266-270. https://doi.org/10.1038/282266a0
Orr, Harry T. ; Lancet, Doron ; Robb, Richard J. ; De Castro, José A.Lopez ; Strominger, Jack L. / The heavy chain of human histocompatibility antigen HLA-B7 contains an immunoglobulin-like region. In: Nature. 1979 ; Vol. 282, No. 5736. pp. 266-270.
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