The HBV Drugs Work: Now What?

Research output: Contribution to journalShort surveypeer-review


Chemotherapeutic agents for Hepatitis B virus (HBV) suppression work, but only when administered to the patient. They do not appear to promote durable, long-term immunological control. After 3 years of effective anti-HBV therapy, a small percentage of patients maintained good control, manifest by controlled serum liver enzymes, low-level HBV-DNA, and controlled HBsAg concentrations. However, this did not occur in the majority of patients. We need a better understanding of the defects in HBV immunity and how to induce effective reconstitution that will maintain viral suppression, albeit either through innate or adaptive immunity.

Original languageEnglish (US)
Pages (from-to)1295-1296
Number of pages2
JournalAmerican Journal of Gastroenterology
Issue number9
StatePublished - Sep 1 2016


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