The gut microbiome of nonhuman primates

Lessons in ecology and evolution

Jonathan B Clayton, Andres Gomez, Katherine Amato, Dan Knights, Dominic A Travis, Ran Blekhman, Rob Knight, Steven Leigh, Rebecca Stumpf, Tiffany M Wolf, Kenneth E. Glander, Francis Cabana, Tim Johnson

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

The mammalian gastrointestinal (GI) tract is home to trillions of bacteria that play a substantial role in host metabolism and immunity. While progress has been made in understanding the role that microbial communities play in human health and disease, much less attention has been given to host-associated microbiomes in nonhuman primates (NHPs). Here we review past and current research exploring the gut microbiome of NHPs. First, we summarize methods for characterization of the NHP gut microbiome. Then we discuss variation in gut microbiome composition and function across different NHP taxa. Finally, we highlight how studying the gut microbiome offers new insights into primate nutrition, physiology, and immune system function, as well as enhances our understanding of primate ecology and evolution. Microbiome approaches are useful tools for studying relevant issues in primate ecology. Further study of the gut microbiome of NHPs will offer new insight into primate ecology and evolution as well as human health.

Original languageEnglish (US)
Article numbere22867
JournalAmerican journal of primatology
Volume80
Issue number6
DOIs
StatePublished - Jun 1 2018

Fingerprint

primate
Primates
digestive system
ecology
human health
nutrition physiology
health and disease
microbiome
immune system
immunity
human diseases
gastrointestinal system
physiology
microbial communities
nutrition
microbial community
metabolism
bacterium
bacteria

Keywords

  • ecology
  • evolution
  • microbiome
  • nonhuman primate (NHP)

PubMed: MeSH publication types

  • Journal Article
  • Review
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, N.I.H., Extramural

Cite this

The gut microbiome of nonhuman primates : Lessons in ecology and evolution. / Clayton, Jonathan B; Gomez, Andres; Amato, Katherine; Knights, Dan; Travis, Dominic A; Blekhman, Ran; Knight, Rob; Leigh, Steven; Stumpf, Rebecca; Wolf, Tiffany M; Glander, Kenneth E.; Cabana, Francis; Johnson, Tim.

In: American journal of primatology, Vol. 80, No. 6, e22867, 01.06.2018.

Research output: Contribution to journalReview article

Clayton, Jonathan B ; Gomez, Andres ; Amato, Katherine ; Knights, Dan ; Travis, Dominic A ; Blekhman, Ran ; Knight, Rob ; Leigh, Steven ; Stumpf, Rebecca ; Wolf, Tiffany M ; Glander, Kenneth E. ; Cabana, Francis ; Johnson, Tim. / The gut microbiome of nonhuman primates : Lessons in ecology and evolution. In: American journal of primatology. 2018 ; Vol. 80, No. 6.
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AU - Leigh, Steven

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