The GSK3β signaling cascade and neurodegenerative disease

Michael D. Kaytor, Harry T. Orr

Research output: Contribution to journalReview articlepeer-review

191 Scopus citations


Biochemical signaling pathways are known to have a critical role in neuronal development and function. A growing body of evidence is accumulating to suggest that signaling pathways also underlie neurodegeneration and neurodegenerative disease. One pathway with a prominent role in neurodegenerative disease is the signaling pathway in which the enzyme glycogen synthase kinase 3 (GSK3) is a key component. In vitro and in vivo evidence point to a key role for GSK3 in promoting neurodegeneration and in Alzheimer's disease plaque and neurofibrillary tangle formation. How GSK3 acts in this regard is still open to debate, but it may involve both extracellular and nuclear apoptotic activities.

Original languageEnglish (US)
Pages (from-to)275-278
Number of pages4
JournalCurrent opinion in neurobiology
Issue number3
StatePublished - Jun 1 2002


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