TY - JOUR
T1 - The Grand Challenges of Organ Banking
T2 - Proceedings from the first global summit on complex tissue cryopreservation
AU - Lewis, Jedediah K.
AU - Bischof, John C.
AU - Braslavsky, Ido
AU - Brockbank, Kelvin G.M.
AU - Fahy, Gregory M.
AU - Fuller, Barry J.
AU - Rabin, Yoed
AU - Tocchio, Alessandro
AU - Woods, Erik J.
AU - Wowk, Brian G.
AU - Acker, Jason P.
AU - Giwa, Sebastian
N1 - Publisher Copyright:
© 2015.
PY - 2016/4/1
Y1 - 2016/4/1
N2 - The first Organ Banking Summit was convened from Feb. 27 - March 1, 2015 in Palo Alto, CA, with events at Stanford University, NASA Research Park, and Lawrence Berkeley National Labs. Experts at the summit outlined the potential public health impact of organ banking, discussed the major remaining scientific challenges that need to be overcome in order to bank organs, and identified key opportunities to accelerate progress toward this goal. Many areas of public health could be revolutionized by the banking of organs and other complex tissues, including transplantation, oncofertility, tissue engineering, trauma medicine and emergency preparedness, basic biomedical research and drug discovery - and even space travel. Key remaining scientific sub-challenges were discussed including ice nucleation and growth, cryoprotectant and osmotic toxicities, chilling injury, thermo-mechanical stress, the need for rapid and uniform rewarming, and ischemia/reperfusion injury. A variety of opportunities to overcome these challenge areas were discussed, i.e. preconditioning for enhanced stress tolerance, nanoparticle rewarming, cyroprotectant screening strategies, and the use of cryoprotectant cocktails including ice binding agents.
AB - The first Organ Banking Summit was convened from Feb. 27 - March 1, 2015 in Palo Alto, CA, with events at Stanford University, NASA Research Park, and Lawrence Berkeley National Labs. Experts at the summit outlined the potential public health impact of organ banking, discussed the major remaining scientific challenges that need to be overcome in order to bank organs, and identified key opportunities to accelerate progress toward this goal. Many areas of public health could be revolutionized by the banking of organs and other complex tissues, including transplantation, oncofertility, tissue engineering, trauma medicine and emergency preparedness, basic biomedical research and drug discovery - and even space travel. Key remaining scientific sub-challenges were discussed including ice nucleation and growth, cryoprotectant and osmotic toxicities, chilling injury, thermo-mechanical stress, the need for rapid and uniform rewarming, and ischemia/reperfusion injury. A variety of opportunities to overcome these challenge areas were discussed, i.e. preconditioning for enhanced stress tolerance, nanoparticle rewarming, cyroprotectant screening strategies, and the use of cryoprotectant cocktails including ice binding agents.
KW - Antifreeze proteins
KW - Chilling injury
KW - Cryobanking
KW - Cryomacroscopy
KW - Cryoprotectant screening
KW - Cryoprotectant toxicity
KW - Devitrification
KW - Freeze tolerance
KW - Ice binding proteins
KW - Ischemia
KW - Ischemic preconditioning
KW - Nanoparticle warming
KW - Organ banking
KW - Organ preservation
KW - Organ transplantation
KW - Perfusion
KW - Persufflation
KW - Thermo-mechanical stress
KW - Vitrification
UR - http://www.scopus.com/inward/record.url?scp=84964662709&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84964662709&partnerID=8YFLogxK
U2 - 10.1016/j.cryobiol.2015.12.001
DO - 10.1016/j.cryobiol.2015.12.001
M3 - Article
C2 - 26687388
AN - SCOPUS:84964662709
SN - 0011-2240
VL - 72
SP - 169
EP - 182
JO - Cryobiology
JF - Cryobiology
IS - 2
ER -