The glymphatic system: Current understanding and modeling

Tomas Bohr; Poul G. Hjorth; Sebastian C. Holst; Sabina Hrabětová; Vesa Kiviniemi; Tuomas Lilius; Iben Lundgaard; Kent Andre Mardal; Erik A. Martens; Yuki Mori; U. Valentin Nägerl; Charles Nicholson; Allen Tannenbaum; John H. Thomas; Jeffrey Tithof; Helene Benveniste; Jeffrey J. Iliff; Douglas H. Kelley; Maiken Nedergaard

doi:10.1016/j.isci.2022.104987

The glymphatic system: Current understanding and modeling

Tomas Bohr, Poul G. Hjorth, Sebastian C. Holst, Sabina Hrabětová, Vesa Kiviniemi, Tuomas Lilius, Iben Lundgaard, Kent Andre Mardal, Erik A. Martens, Yuki Mori, U. Valentin Nägerl, Charles Nicholson, Allen Tannenbaum, John H. Thomas, Jeffrey Tithof, Helene Benveniste, Jeffrey J. Iliff, Douglas H. Kelley, Maiken Nedergaard

Research output: Contribution to journal › Review article › peer-review

103 Scopus citations

Abstract

We review theoretical and numerical models of the glymphatic system, which circulates cerebrospinal fluid and interstitial fluid around the brain, facilitating solute transport. Models enable hypothesis development and predictions of transport, with clinical applications including drug delivery, stroke, cardiac arrest, and neurodegenerative disorders like Alzheimer's disease. We sort existing models into broad categories by anatomical function: Perivascular flow, transport in brain parenchyma, interfaces to perivascular spaces, efflux routes, and links to neuronal activity. Needs and opportunities for future work are highlighted wherever possible; new models, expanded models, and novel experiments to inform models could all have tremendous value for advancing the field.

Original language	English (US)
Article number	104987
Journal	iScience
Volume	25
Issue number	9
DOIs	https://doi.org/10.1016/j.isci.2022.104987
State	Published - Sep 16 2022
Externally published	Yes

Bibliographical note

Funding Information:
All authors attended the workshop “The glymphatic system: From theoretical models to clinical applications,” engaged in extended discussion, and wrote the paper collaboratively. We declare no conflicts of interest.

Publisher Copyright:
© 2022 The Author(s)

Keywords

Neuroanatomy
Neuroscience
Systems biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.isci.2022.104987

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Bohr, T., Hjorth, P. G., Holst, S. C., Hrabětová, S., Kiviniemi, V., Lilius, T., Lundgaard, I., Mardal, K. A., Martens, E. A., Mori, Y., Nägerl, U. V., Nicholson, C., Tannenbaum, A., Thomas, J. H., Tithof, J., Benveniste, H., Iliff, J. J., Kelley, D. H., & Nedergaard, M. (2022). The glymphatic system: Current understanding and modeling. iScience, 25(9), Article 104987. https://doi.org/10.1016/j.isci.2022.104987

Bohr, T, Hjorth, PG, Holst, SC, Hrabětová, S, Kiviniemi, V, Lilius, T, Lundgaard, I, Mardal, KA, Martens, EA, Mori, Y, Nägerl, UV, Nicholson, C, Tannenbaum, A, Thomas, JH, Tithof, J, Benveniste, H, Iliff, JJ, Kelley, DH & Nedergaard, M 2022, 'The glymphatic system: Current understanding and modeling', iScience, vol. 25, no. 9, 104987. https://doi.org/10.1016/j.isci.2022.104987

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abstract = "We review theoretical and numerical models of the glymphatic system, which circulates cerebrospinal fluid and interstitial fluid around the brain, facilitating solute transport. Models enable hypothesis development and predictions of transport, with clinical applications including drug delivery, stroke, cardiac arrest, and neurodegenerative disorders like Alzheimer's disease. We sort existing models into broad categories by anatomical function: Perivascular flow, transport in brain parenchyma, interfaces to perivascular spaces, efflux routes, and links to neuronal activity. Needs and opportunities for future work are highlighted wherever possible; new models, expanded models, and novel experiments to inform models could all have tremendous value for advancing the field.",

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note = "Funding Information: All authors attended the workshop “The glymphatic system: From theoretical models to clinical applications,” engaged in extended discussion, and wrote the paper collaboratively. We declare no conflicts of interest. Publisher Copyright: {\textcopyright} 2022 The Author(s)",

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AU - Hjorth, Poul G.

AU - Holst, Sebastian C.

AU - Hrabětová, Sabina

AU - Kiviniemi, Vesa

AU - Lilius, Tuomas

AU - Lundgaard, Iben

AU - Mardal, Kent Andre

AU - Martens, Erik A.

AU - Mori, Yuki

AU - Nägerl, U. Valentin

AU - Nicholson, Charles

AU - Tannenbaum, Allen

AU - Thomas, John H.

AU - Tithof, Jeffrey

AU - Benveniste, Helene

AU - Iliff, Jeffrey J.

AU - Kelley, Douglas H.

AU - Nedergaard, Maiken

N1 - Funding Information: All authors attended the workshop “The glymphatic system: From theoretical models to clinical applications,” engaged in extended discussion, and wrote the paper collaboratively. We declare no conflicts of interest. Publisher Copyright: © 2022 The Author(s)

PY - 2022/9/16

Y1 - 2022/9/16

N2 - We review theoretical and numerical models of the glymphatic system, which circulates cerebrospinal fluid and interstitial fluid around the brain, facilitating solute transport. Models enable hypothesis development and predictions of transport, with clinical applications including drug delivery, stroke, cardiac arrest, and neurodegenerative disorders like Alzheimer's disease. We sort existing models into broad categories by anatomical function: Perivascular flow, transport in brain parenchyma, interfaces to perivascular spaces, efflux routes, and links to neuronal activity. Needs and opportunities for future work are highlighted wherever possible; new models, expanded models, and novel experiments to inform models could all have tremendous value for advancing the field.

AB - We review theoretical and numerical models of the glymphatic system, which circulates cerebrospinal fluid and interstitial fluid around the brain, facilitating solute transport. Models enable hypothesis development and predictions of transport, with clinical applications including drug delivery, stroke, cardiac arrest, and neurodegenerative disorders like Alzheimer's disease. We sort existing models into broad categories by anatomical function: Perivascular flow, transport in brain parenchyma, interfaces to perivascular spaces, efflux routes, and links to neuronal activity. Needs and opportunities for future work are highlighted wherever possible; new models, expanded models, and novel experiments to inform models could all have tremendous value for advancing the field.

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The glymphatic system: Current understanding and modeling

Abstract

Bibliographical note

Keywords

UN SDGs

Publisher link

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