The Glomerular Mesangium

Alfred F. Michael, Youngki Kim

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

The mesangium is more than simply a support structure for glomerular capillary circulation. Mesangial cells respond to various vasoactive mediators and probably contribute to the regulation of mesangial cell contractility and, consequently, glomerular perfusion. The surrounding extracellular matrix contains several glycoproteins and collagens that may affect the immune interactions of antigens and antibodies and may possibly influence the disposition of immune complexes. These properties may modulate the consequences of deposition of IgA-containing immune complexes in the mesangium in patients with IgA nephropathy and the consequent expression of clinical disease.

Original languageEnglish (US)
Pages (from-to)393-396
Number of pages4
JournalAmerican Journal of Kidney Diseases
Volume12
Issue number5
DOIs
StatePublished - 1988

Keywords

  • IgA nephropathy
  • collagen
  • matrix
  • mesangium
  • pathogenesis

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