The global virulence regulators VsrAD and PhcA control secondary metabolism in the plant pathogen ralstonia solanacearum

Patrick Schneider; Jonathan M. Jacobs; João Neres; Courtney C. Aldrich; Caitilyn Allen; Markus Nett; Dirk Hoffmeister

doi:10.1002/cbic.200900510

The global virulence regulators VsrAD and PhcA control secondary metabolism in the plant pathogen ralstonia solanacearum

Patrick Schneider, Jonathan M. Jacobs, João Neres, Courtney C. Aldrich, Caitilyn Allen, Markus Nett, Dirk Hoffmeister

Medicinal Chemistry

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

(Chemical Equation Presented) Two transcriptional regulators in the bacterium Ralstonia solanacearum (VsrAD and PhcA) that play a central role for virulence were shown to affect secondary metabolism as well; this led to the identification of a new natural product, ralfuranone. The results shed light on the regulation and biosynthetic capacities for secondary metabolism of this plant pathogen.

Original language	English (US)
Pages (from-to)	2730-2732
Number of pages	3
Journal	ChemBioChem
Volume	10
Issue number	17
DOIs	https://doi.org/10.1002/cbic.200900510
State	Published - Nov 23 2009

Keywords

Metabolism
Natural products
Plant pathogens
Ralstonia solanacearum
Regulators

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10.1002/cbic.200900510

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abstract = "(Chemical Equation Presented) Two transcriptional regulators in the bacterium Ralstonia solanacearum (VsrAD and PhcA) that play a central role for virulence were shown to affect secondary metabolism as well; this led to the identification of a new natural product, ralfuranone. The results shed light on the regulation and biosynthetic capacities for secondary metabolism of this plant pathogen.",

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AU - Neres, João

AU - Aldrich, Courtney C.

AU - Allen, Caitilyn

AU - Nett, Markus

AU - Hoffmeister, Dirk

PY - 2009/11/23

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AB - (Chemical Equation Presented) Two transcriptional regulators in the bacterium Ralstonia solanacearum (VsrAD and PhcA) that play a central role for virulence were shown to affect secondary metabolism as well; this led to the identification of a new natural product, ralfuranone. The results shed light on the regulation and biosynthetic capacities for secondary metabolism of this plant pathogen.

KW - Metabolism

KW - Natural products

KW - Plant pathogens

KW - Ralstonia solanacearum

KW - Regulators

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The global virulence regulators VsrAD and PhcA control secondary metabolism in the plant pathogen ralstonia solanacearum

Abstract

Keywords

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