The genetics of neurodegenerative diseases

John Hardy, Harry Orr

Research output: Contribution to journalReview articlepeer-review

61 Scopus citations


In the last 50 years, an enormous amount of progress has been made in dissecting the etiology of hereditary neurodegenerative diseases, including the dementias, the parkinsonisms, the ataxias and the motor-neuron diseases. In addition, these genetic findings are beginning to provide insights into the pathogeneses of the sporadic forms of the diseases. Through animal and cellular modeling studies we are beginning to gain insights into the pathogenic pathways to disease. This mechanistic understanding is now leading to therapeutic strategies based on this new understanding. As yet, however, no mechanistic therapies are in use in the clinic.

Original languageEnglish (US)
Pages (from-to)1690-1699
Number of pages10
JournalJournal of Neurochemistry
Issue number6
StatePublished - Jun 2006


  • Ataxia
  • Dementia
  • Parkinsonism
  • Polyglutamine
  • Tau
  • α-synuclein


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