The genetic epidemiology of schizophrenia and the design of linkage studies

M. McGue, I. I. Gottesman

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

There are three aspects of schizophrenia that are challenges to the design of linkage studies. First, analysis of twin and family data have consistently failed to identify a single major gene effect. Second, ascertainment of multiplex families does not guarantee the sampling of families in whom a major gene is segregating even if such a gene exists. Third, environmental influences appear to play an essential role in the etiology of at least some schizophrenia. The implications of these features for linkage strategies in schizophrenia are discussed.

Original languageEnglish (US)
Pages (from-to)174-181
Number of pages8
JournalEuropean Archives of Psychiatry and Clinical Neuroscience
Volume240
Issue number3
DOIs
StatePublished - Feb 1 1991

Keywords

  • Genetic epidemiology
  • Genetic models
  • Linkage
  • Schizophrenia

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