The Future of Cardiac Magnetic Resonance Clinical Trials

Society for Cardiovascular Magnetic Resonance

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Over the past 2 decades, cardiac magnetic resonance (CMR) has become an essential component of cardiovascular clinical care and contributed to imaging-guided diagnosis and management of coronary artery disease, cardiomyopathy, congenital heart disease, cardio-oncology, valvular, and vascular disease, amongst others. The widespread availability, safety, and capability of CMR to provide corresponding anatomical, physiological, and functional data in 1 imaging session can improve the design and conduct of clinical trials through both a reduction of sample size and provision of important mechanistic data that may augment clinical trial findings. Moreover, prospective imaging-guided strategies using CMR can enhance safety, efficacy, and cost-effectiveness of cardiovascular pathways in clinical practice around the world. As the future of large-scale clinical trial design evolves to integrate personalized medicine, cost-effectiveness, and mechanistic insights of novel therapies, the integration of CMR will continue to play a critical role. In this document, the attributes, limitations, and challenges of CMR's integration into the future design and conduct of clinical trials will also be covered, and recommendations for trialists will be explored. Several prominent examples of clinical trials that test the efficacy of CMR-imaging guided pathways will also be discussed.

Original languageEnglish (US)
Pages (from-to)2127-2138
Number of pages12
JournalJACC: Cardiovascular Imaging
Issue number12
StatePublished - Dec 2022

Bibliographical note

Funding Information:
Dr Petersen provides consultant services to and is a shareholder in Circle Cardiovascular Imaging, Inc. Dr Nagel has received speaker fees, consulting fees, and grant support from Bayer AG; and has received research grant support from NeoSoft. Dr Bilchick has received research grant support from Siemens Healthineers and Medtronic, Inc. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.

Publisher Copyright:
© 2022 American College of Cardiology Foundation


  • cardiac magnetic resonance
  • clinical trials


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