The future for antibiotics: Bacterial membrane disintegrators

Nathan A. Lockwood, Kevin H Mayo

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations


Bacterial resistance to conventional antibiotics is an ever increasing problem in the treatment of infectious disease. The basic problem is that conventional antibiotics, which generally operate by inhibiting some bacterial enzyme(s), can be rendered ineffective by overuse, natural selection and induced bacterial mutations. A novel class of antibiotics that functions by disrupting the superstructure of bacterial membranes rather than by inhibiting any specific enzyme has presented itself as the future for antibiotics. Most of these bactericidal agents are peptides of peptide-based molecules that have been either isolated from natural sources or synthetically designed. Here we review recent research into the development of peptides as bacterial membrane-disintegrating agents.

Original languageEnglish (US)
Pages (from-to)911-923
Number of pages13
JournalDrugs of the Future
Issue number9
StatePublished - Sep 2003


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