The florida pancreas collaborative next-generation biobank: Infrastructure to reduce disparities and improve survival for a diverse cohort of patients with pancreatic cancer

Florida Pancreas Collaborative

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Background: Well-annotated, high-quality biorepositories provide a valuable platform to support translational research. However, most biorepositories have poor representation of minority groups, limiting the ability to address health disparities. Methods: We describe the establishment of the Florida Pancreas Collaborative (FPC), the first state-wide prospective cohort study and biorepository designed to address the higher burden of pancreatic cancer (PaCa) in African Americans (AA) compared to Non-Hispanic Whites (NHW) and Hispanic/Latinx (H/L). We provide an overview of stakeholders; study eligibility and design; recruitment strategies; standard operating procedures to collect, process, store, and transfer biospecimens, medical images, and data; our cloud-based data management platform; and progress regarding recruitment and biobanking. Results: The FPC consists of multidisciplinary teams from fifteen Florida medical institutions. From March 2019 through August 2020, 350 patients were assessed for eligibility, 323 met inclusion/exclusion criteria, and 305 (94%) enrolled, including 228 NHW, 30 AA, and 47 H/L, with 94%, 100%, and 94% participation rates, respectively. A high percentage of participants have donated blood (87%), pancreatic tumor tissue (41%), computed tomography scans (76%), and questionnaires (62%). Conclusions: This biorepository addresses a critical gap in PaCa research and has potential to advance translational studies intended to minimize disparities and reduce PaCa-related morbidity and mortality.

Original languageEnglish (US)
Article number809
Pages (from-to)1-24
Number of pages24
Issue number4
StatePublished - Feb 2 2021
Externally publishedYes

Bibliographical note

Funding Information:
Funding: The research in this publication was supported in part by the James and Esther King Biomedical Research Program, Florida Department of Health (Grant #8JK02; awarded to J.B.P. and J.G.T.), and the Tissue Core, Quantitative Imaging Core, the Participant Research, Interventions, and Measurement (PRISM) Core, the Biostatistics and Bioinformatics Shared Resource, and the Pharmacokinetics and Pharmacodynamics Core at the H. Lee Moffitt Cancer Center & Research Institute, an NCI designated Comprehensive Cancer Center (P30-CA076292). The content is solely the responsibility of the authors and does not necessarily represent the official views of the sponsors or the participating institutions.

Funding Information:
The Florida Pancreas Collaborative (FPC) was founded in 2015 by investigators (JBP, MPM, JGT, NBM) from the three main academic cancer centers based in Florida: Moffitt Cancer Center and Research Institute (MCC, Tampa), the University of Florida Health Cancer Center (UFG, Gainesville), and the Sylvester Comprehensive Cancer Center/University of Miami (UOM, Miami) [24]. Florida Agency for Health Care Administration (AHCA) [25] inpatient discharge data was used to identify institutions throughout Florida with the highest numbers of AA, H/L, and NHW individuals diagnosed and treated for PaCa. We then used internet queries and our professional network to identify and contact clinicians (primarily surgeons and oncologists) to assess interest in participation. Requirements for participation included having a dedicated site principal investigator (PI), institutional support/backing, and willingness to contribute to a common biorepository using standard operating procedures (SOPs). With grant funding from the State of Florida’s James and Esther King Biomedical Research Program in 2018, the FPC expanded to include twelve additional institutions (academic and community cancer centers and private hospitals)

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.


  • Biorepository
  • Cancer disparities
  • Pancreatic cancer
  • Prospective cohort
  • Underserved populations


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