The first synthesis of a C-9 carbonyl modified baccatin III derivative and its conversion to novel taxol® and taxotere® analogues

Apurba Datta; Jeffrey Aubé; Gunda I. Georg; Lester A. Mitscher; Lalith R. Jayasinghe

doi:10.1016/S0960-894X(01)80379-6

The first synthesis of a C-9 carbonyl modified baccatin III derivative and its conversion to novel taxol^® and taxotere^® analogues

Apurba Datta
, Jeffrey Aubé
, Gunda I. Georg
, Lester A. Mitscher
, Lalith R. Jayasinghe

Medicinal Chemistry

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Treatment of 7,10-ditrocbaccatin III with potassium tert-butoxide resulted in the formation of a cyclic carbonate. Its taxol and taxotere analogues were found to possess good microtubule assembly properties but exhibited poor in vitro cytotoxicity against B16 melanoma cells.

Original language	English (US)
Pages (from-to)	1831-1834
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	4
Issue number	15
DOIs	https://doi.org/10.1016/S0960-894X(01)80379-6
State	Published - Aug 11 1994

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SDG 3 Good Health and Well-being

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10.1016/S0960-894X(01)80379-6

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title = "The first synthesis of a C-9 carbonyl modified baccatin III derivative and its conversion to novel taxol{\textregistered} and taxotere{\textregistered} analogues",

abstract = "Treatment of 7,10-ditrocbaccatin III with potassium tert-butoxide resulted in the formation of a cyclic carbonate. Its taxol and taxotere analogues were found to possess good microtubule assembly properties but exhibited poor in vitro cytotoxicity against B16 melanoma cells.",

author = "Apurba Datta and Jeffrey Aub{\'e} and Georg, \{Gunda I.\} and Mitscher, \{Lester A.\} and Jayasinghe, \{Lalith R.\}",

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AU - Datta, Apurba

AU - Aubé, Jeffrey

AU - Georg, Gunda I.

AU - Mitscher, Lester A.

AU - Jayasinghe, Lalith R.

PY - 1994/8/11

Y1 - 1994/8/11

N2 - Treatment of 7,10-ditrocbaccatin III with potassium tert-butoxide resulted in the formation of a cyclic carbonate. Its taxol and taxotere analogues were found to possess good microtubule assembly properties but exhibited poor in vitro cytotoxicity against B16 melanoma cells.

AB - Treatment of 7,10-ditrocbaccatin III with potassium tert-butoxide resulted in the formation of a cyclic carbonate. Its taxol and taxotere analogues were found to possess good microtubule assembly properties but exhibited poor in vitro cytotoxicity against B16 melanoma cells.

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DO - 10.1016/S0960-894X(01)80379-6

M3 - Article

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SN - 0960-894X

VL - 4

SP - 1831

EP - 1834

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 15

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