The FGF/FGF receptor axis as a therapeutic target in breast cancer

Nicholas J. Brady, Pavlina Chuntova, Lindsey K. Bade, Kathryn L. Schwertfeger

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations

Abstract

FGF receptor (FGFR) signaling is a vital component of both embryonic and postnatal mammary gland development, which has prompted researchers to investigate both its relevance to breast cancer and its potential as a therapeutic target. Deregulated FGFR signaling during breast cancer occurs through various mechanisms, including amplification of the receptor genes, aberrant ligand expression, receptor mutations and translocations. Recent experimental outcomes involving both animal models and human breast cancer cell lines have led to the initiation of multiple early clinical trials investigating the safety and efficacy of small-molecule FGFR inhibitors. In this article, the authors review both the most recent discoveries and the need for further investigation of the mechanisms through which FGF/FGFR signaling has emerged as an oncogenic driver.

Original languageEnglish (US)
Pages (from-to)391-402
Number of pages12
JournalExpert Review of Endocrinology and Metabolism
Volume8
Issue number4
DOIs
StatePublished - Jul 2013

Keywords

  • breast cancer
  • fibroblast growth factor
  • fibroblast growth factor receptor
  • mammary gland
  • receptor tyrosine kinase
  • targeted therapies

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