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The FEMA GRAS assessment of trans-anethole used as a flavouring substance
P. Newberne
, R. L. Smith
, J. Doull
, J. I. Goodman
, I. C. Munro
, P. S. Portoghese
, B. M. Wagner
, C. S. Weil
, L. A. Woods
, T. B. Adams
, C. D. Lucas
, R. A. Ford
Medicinal Chemistry
Research output
:
Contribution to journal
›
Review article
›
peer-review
138
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Scopus citations
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Keyphrases
Flavor Compounds
100%
Trans-anethole
100%
Epoxides
92%
Anethole
92%
Female Rats
28%
Hepatotoxicity
28%
Dietary Studies
28%
High Dose
21%
Exposure Level
21%
Safety Assessment
14%
Expert Panel
14%
Epoxidation
14%
Metabolic Detoxication
14%
Dose Level
14%
Cell Proliferation
7%
Evaluation Use
7%
Cytotoxicity
7%
Dietary Intake
7%
Pathological Changes
7%
Cell-to-cell
7%
Rodents
7%
Mechanistic Approach
7%
Soluble Epoxide Hydrolase
7%
Genotoxicity
7%
Low Incidence
7%
Significant Risk Factors
7%
Subchronic
7%
Liver Tumor
7%
Hepatotoxic
7%
Laboratory Mice
7%
Intended Use
7%
Mutagenic Potential
7%
Genotoxic Potential
7%
NOAEL
7%
Human Health Risk
7%
Induced Hepatotoxicity
7%
Cumulative Exposure
7%
Weight of Evidence
7%
Cell Necrosis
7%
Continuous Exposure
7%
Hepatocellular Tumors
7%
Hepatocarcinogen
7%
Non-genotoxic
7%
Metabolic Shift
7%
Conservative Model
7%
Detoxication Enzymes
7%
Genotoxic Mechanism
7%
O-demethylation
7%
Rat Hepatotoxicity
7%
Chronic Hepatopathies
7%
Low Activity
7%
Comprehensive Program
7%
Dose-dependent
7%
Evidence-based Support
7%
Fast-acting
7%
Female Sprague-Dawley Rats
7%
Pharmacology, Toxicology and Pharmaceutical Science
Anethole
100%
Epoxide
48%
Hepatotoxicity
29%
Rat
25%
Detoxication
11%
Genotoxicity
3%
Sprague Dawley Rat
3%
Necrosis
3%
Epoxide Hydrolase
3%
Enzymes
3%
Liver Tumor
3%
No-Observed-Adverse-Effect Level
3%
Cytotoxicity
3%