The FEMA GRAS assessment of pyrazine derivatives used as flavor ingredients

T. B. Adams; J. Doull; V. J. Feron; J. I. Goodman; L. J. Marnett; I. C. Munro; P. M. Newberne; P. S. Portoghese; R. L. Smith; W. J. Waddell; B. M. Wagner

doi:10.1016/S0278-6915(01)00123-5

The FEMA GRAS assessment of pyrazine derivatives used as flavor ingredients

T. B. Adams, J. Doull, V. J. Feron, J. I. Goodman, L. J. Marnett, I. C. Munro, P. M. Newberne, P. S. Portoghese, R. L. Smith, W. J. Waddell, B. M. Wagner

Medicinal Chemistry

Research output: Contribution to journal › Review article › peer-review

99 Scopus citations

Abstract

This is the fifth in a series of safety evaluations performed by the Expert Panel of the Flavor and Extract Manufacturers Association (FEMA). In 1993, the Panel initiated a comprehensive program to re-evaluate the safety of more than 1700 GRAS flavoring substances under conditions of intended use. Elements that are fundamental to the safety evaluation of flavor ingredients include exposure, structural analogy, metabolism, pharmacokinetics and toxicology. Flavor ingredients are evaluated individually taking into account the available scientific information on the group of structurally related substances. Scientific data relevant to the safety evaluation of the use of pyrazine derivatives as flavoring ingredients is evaluated.

Original language	English (US)
Pages (from-to)	429-451
Number of pages	23
Journal	Food and Chemical Toxicology
Volume	40
Issue number	4
DOIs	https://doi.org/10.1016/S0278-6915(01)00123-5
State	Published - 2002

Keywords

Flavoring agents
Food safety
GRAS
Pyrazine derivatives

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10.1016/S0278-6915(01)00123-5

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title = "The FEMA GRAS assessment of pyrazine derivatives used as flavor ingredients",

abstract = "This is the fifth in a series of safety evaluations performed by the Expert Panel of the Flavor and Extract Manufacturers Association (FEMA). In 1993, the Panel initiated a comprehensive program to re-evaluate the safety of more than 1700 GRAS flavoring substances under conditions of intended use. Elements that are fundamental to the safety evaluation of flavor ingredients include exposure, structural analogy, metabolism, pharmacokinetics and toxicology. Flavor ingredients are evaluated individually taking into account the available scientific information on the group of structurally related substances. Scientific data relevant to the safety evaluation of the use of pyrazine derivatives as flavoring ingredients is evaluated.",

keywords = "Flavoring agents, Food safety, GRAS, Pyrazine derivatives",

author = "Adams, {T. B.} and J. Doull and Feron, {V. J.} and Goodman, {J. I.} and Marnett, {L. J.} and Munro, {I. C.} and Newberne, {P. M.} and Portoghese, {P. S.} and Smith, {R. L.} and Waddell, {W. J.} and Wagner, {B. M.}",

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doi = "10.1016/S0278-6915(01)00123-5",

language = "English (US)",

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T1 - The FEMA GRAS assessment of pyrazine derivatives used as flavor ingredients

AU - Adams, T. B.

AU - Doull, J.

AU - Feron, V. J.

AU - Goodman, J. I.

AU - Marnett, L. J.

AU - Munro, I. C.

AU - Newberne, P. M.

AU - Portoghese, P. S.

AU - Smith, R. L.

AU - Waddell, W. J.

AU - Wagner, B. M.

PY - 2002

Y1 - 2002

N2 - This is the fifth in a series of safety evaluations performed by the Expert Panel of the Flavor and Extract Manufacturers Association (FEMA). In 1993, the Panel initiated a comprehensive program to re-evaluate the safety of more than 1700 GRAS flavoring substances under conditions of intended use. Elements that are fundamental to the safety evaluation of flavor ingredients include exposure, structural analogy, metabolism, pharmacokinetics and toxicology. Flavor ingredients are evaluated individually taking into account the available scientific information on the group of structurally related substances. Scientific data relevant to the safety evaluation of the use of pyrazine derivatives as flavoring ingredients is evaluated.

AB - This is the fifth in a series of safety evaluations performed by the Expert Panel of the Flavor and Extract Manufacturers Association (FEMA). In 1993, the Panel initiated a comprehensive program to re-evaluate the safety of more than 1700 GRAS flavoring substances under conditions of intended use. Elements that are fundamental to the safety evaluation of flavor ingredients include exposure, structural analogy, metabolism, pharmacokinetics and toxicology. Flavor ingredients are evaluated individually taking into account the available scientific information on the group of structurally related substances. Scientific data relevant to the safety evaluation of the use of pyrazine derivatives as flavoring ingredients is evaluated.

KW - Flavoring agents

KW - Food safety

KW - GRAS

KW - Pyrazine derivatives

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U2 - 10.1016/S0278-6915(01)00123-5

DO - 10.1016/S0278-6915(01)00123-5

M3 - Review article

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AN - SCOPUS:18344375055

SN - 0278-6915

VL - 40

SP - 429

EP - 451

JO - Food and Chemical Toxicology

JF - Food and Chemical Toxicology

IS - 4

ER -

The FEMA GRAS assessment of pyrazine derivatives used as flavor ingredients

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