The FaceBase Consortium: A comprehensive program to facilitate craniofacial research

Harry Hochheiser; Bruce J. Aronow; Kristin Artinger; Terri H. Beaty; James F. Brinkley; Yang Chai; David Clouthier; Michael L. Cunningham; Michael Dixon; Leah Rae Donahue; Scott E. Fraser; Benedikt Hallgrimsson; Junichi Iwata; Ophir Klein; Mary L. Marazita; Jeffrey C. Murray; Stephen Murray; Fernando Pardo Manuel de Villena; John Postlethwait; Steven Potter; Linda Shapiro; Richard A. Spritz; Axel Visel; Seth M. Weinberg; Paul A. Trainor

doi:10.1016/j.ydbio.2011.02.033

The FaceBase Consortium: A comprehensive program to facilitate craniofacial research

Harry Hochheiser, Bruce J. Aronow, Kristin Artinger, Terri H. Beaty, James F. Brinkley, Yang Chai, David Clouthier, Michael L. Cunningham, Michael Dixon, Leah Rae Donahue, Scott E. Fraser, Benedikt Hallgrimsson, Junichi Iwata, Ophir Klein, Mary L. Marazita, Jeffrey C. Murray, Stephen Murray, Fernando Pardo Manuel de Villena, John Postlethwait, Steven PotterLinda Shapiro, Richard A. Spritz, Axel Visel, Seth M. Weinberg, Paul A. Trainor

Research output: Contribution to journal › Article › peer-review

65 Scopus citations

Abstract

The FaceBase Consortium consists of ten interlinked research and technology projects whose goal is to generate craniofacial research data and technology for use by the research community through a central data management and integrated bioinformatics hub. Funded by the National Institute of Dental and Craniofacial Research (NIDCR) and currently focused on studying the development of the middle region of the face, the Consortium will produce comprehensive datasets of global gene expression patterns, regulatory elements and sequencing; will generate anatomical and molecular atlases; will provide human normative facial data and other phenotypes; conduct follow up studies of a completed genome-wide association study; generate independent data on the genetics of craniofacial development, build repositories of animal models and of human samples and data for community access and analysis; and will develop software tools and animal models for analyzing and functionally testing and integrating these data. The FaceBase website (http://www.facebase.org) will serve as a web home for these efforts, providing interactive tools for exploring these datasets, together with discussion forums and other services to support and foster collaboration within the craniofacial research community.

Original language	English (US)
Pages (from-to)	175-182
Number of pages	8
Journal	Developmental Biology
Volume	355
Issue number	2
DOIs	https://doi.org/10.1016/j.ydbio.2011.02.033
State	Published - Jul 15 2011
Externally published	Yes

Bibliographical note

Funding Information:
The FaceBase Consortium thanks the many investigators and staff members for working collaboratively and untiringly toward fulfilling the goals of the program. In particular, we appreciate the vision and support of Dr. Lawrence A. Tabak, former Director of the National Institute of Dental and Craniofacial Research (NIDCR), in enabling this effort. We thank the NIDCR Program Staff for their advice in implementing FaceBase and suggestions for this manuscript (Program Official: Steven Scholnick; Project Scientists: Emily Harris, Nadya Lumelsky, Lillian Shum). We are very grateful to Carolyn Randolph for editorial assistance in preparing this paper. Projects comprising the FaceBase Consortium are supported by grants from the NIDCR , U01-DE20049 (S.S.P., B.A., P.A.T), U01-DE20050 (L.S., M.L.C., J.F.B), U01-DE20052 (L.R.B.D., S.A.M.), U01-DE20054 (R.A.S.), U01-DE020057 (J.C.M., M.L.M., H.H. M.D.), U01-DE20060 (A.V.), U01-DE20063 (S.E.F.), U01-DE20065 (Y.C., J.I.), U01-DE20073 (T.H.B.), U01-DE20076 (D.E.C., K.B.A., J.H.P.) and U01-DE20078 (S.M.W., M.L.M. M.L.C).

Keywords

Animal models
Cleft lip and palate
Craniofacial development
Database
Human genetics
Morphometrics

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10.1016/j.ydbio.2011.02.033

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Hochheiser, H., Aronow, B. J., Artinger, K., Beaty, T. H., Brinkley, J. F., Chai, Y., Clouthier, D., Cunningham, M. L., Dixon, M., Donahue, L. R., Fraser, S. E., Hallgrimsson, B., Iwata, J., Klein, O., Marazita, M. L., Murray, J. C., Murray, S., de Villena, F. P. M., Postlethwait, J., ... Trainor, P. A. (2011). The FaceBase Consortium: A comprehensive program to facilitate craniofacial research. Developmental Biology, 355(2), 175-182. https://doi.org/10.1016/j.ydbio.2011.02.033

Hochheiser, H, Aronow, BJ, Artinger, K, Beaty, TH, Brinkley, JF, Chai, Y, Clouthier, D, Cunningham, ML, Dixon, M, Donahue, LR, Fraser, SE, Hallgrimsson, B, Iwata, J, Klein, O, Marazita, ML, Murray, JC, Murray, S, de Villena, FPM, Postlethwait, J, Potter, S, Shapiro, L, Spritz, RA, Visel, A, Weinberg, SM & Trainor, PA 2011, 'The FaceBase Consortium: A comprehensive program to facilitate craniofacial research', Developmental Biology, vol. 355, no. 2, pp. 175-182. https://doi.org/10.1016/j.ydbio.2011.02.033

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title = "The FaceBase Consortium: A comprehensive program to facilitate craniofacial research",

abstract = "The FaceBase Consortium consists of ten interlinked research and technology projects whose goal is to generate craniofacial research data and technology for use by the research community through a central data management and integrated bioinformatics hub. Funded by the National Institute of Dental and Craniofacial Research (NIDCR) and currently focused on studying the development of the middle region of the face, the Consortium will produce comprehensive datasets of global gene expression patterns, regulatory elements and sequencing; will generate anatomical and molecular atlases; will provide human normative facial data and other phenotypes; conduct follow up studies of a completed genome-wide association study; generate independent data on the genetics of craniofacial development, build repositories of animal models and of human samples and data for community access and analysis; and will develop software tools and animal models for analyzing and functionally testing and integrating these data. The FaceBase website (http://www.facebase.org) will serve as a web home for these efforts, providing interactive tools for exploring these datasets, together with discussion forums and other services to support and foster collaboration within the craniofacial research community.",

keywords = "Animal models, Cleft lip and palate, Craniofacial development, Database, Human genetics, Morphometrics",

author = "Harry Hochheiser and Aronow, \{Bruce J.\} and Kristin Artinger and Beaty, \{Terri H.\} and Brinkley, \{James F.\} and Yang Chai and David Clouthier and Cunningham, \{Michael L.\} and Michael Dixon and Donahue, \{Leah Rae\} and Fraser, \{Scott E.\} and Benedikt Hallgrimsson and Junichi Iwata and Ophir Klein and Marazita, \{Mary L.\} and Murray, \{Jeffrey C.\} and Stephen Murray and \{de Villena\}, \{Fernando Pardo Manuel\} and John Postlethwait and Steven Potter and Linda Shapiro and Spritz, \{Richard A.\} and Axel Visel and Weinberg, \{Seth M.\} and Trainor, \{Paul A.\}",

note = "Funding Information: The FaceBase Consortium thanks the many investigators and staff members for working collaboratively and untiringly toward fulfilling the goals of the program. In particular, we appreciate the vision and support of Dr. Lawrence A. Tabak, former Director of the National Institute of Dental and Craniofacial Research (NIDCR), in enabling this effort. We thank the NIDCR Program Staff for their advice in implementing FaceBase and suggestions for this manuscript (Program Official: Steven Scholnick; Project Scientists: Emily Harris, Nadya Lumelsky, Lillian Shum). We are very grateful to Carolyn Randolph for editorial assistance in preparing this paper. Projects comprising the FaceBase Consortium are supported by grants from the NIDCR , U01-DE20049 (S.S.P., B.A., P.A.T), U01-DE20050 (L.S., M.L.C., J.F.B), U01-DE20052 (L.R.B.D., S.A.M.), U01-DE20054 (R.A.S.), U01-DE020057 (J.C.M., M.L.M., H.H. M.D.), U01-DE20060 (A.V.), U01-DE20063 (S.E.F.), U01-DE20065 (Y.C., J.I.), U01-DE20073 (T.H.B.), U01-DE20076 (D.E.C., K.B.A., J.H.P.) and U01-DE20078 (S.M.W., M.L.M. M.L.C).",

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AU - Artinger, Kristin

AU - Beaty, Terri H.

AU - Brinkley, James F.

AU - Chai, Yang

AU - Clouthier, David

AU - Cunningham, Michael L.

AU - Dixon, Michael

AU - Donahue, Leah Rae

AU - Fraser, Scott E.

AU - Hallgrimsson, Benedikt

AU - Iwata, Junichi

AU - Klein, Ophir

AU - Marazita, Mary L.

AU - Murray, Jeffrey C.

AU - Murray, Stephen

AU - de Villena, Fernando Pardo Manuel

AU - Postlethwait, John

AU - Potter, Steven

AU - Shapiro, Linda

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AU - Weinberg, Seth M.

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KW - Cleft lip and palate

KW - Craniofacial development

KW - Database

KW - Human genetics

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The FaceBase Consortium: A comprehensive program to facilitate craniofacial research

Abstract

Bibliographical note

Keywords

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