The evolutionary ecology of circadian rhythms in infection

Mary L. Westwood, Aidan J. O’Donnell, Charissa de Bekker, Curtis M. Lively, Marlene Zuk, Sarah E. Reece

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations

Abstract

Biological rhythms coordinate organisms’ activities with daily rhythms in the environment. For parasites, this includes rhythms in both the external abiotic environment and the within-host biotic environment. Hosts exhibit rhythms in behaviours and physiologies, including immune responses, and parasites exhibit rhythms in traits underpinning virulence and transmission. Yet, the evolutionary and ecological drivers of rhythms in traits underpinning host defence and parasite offence are largely unknown. Here, we explore how hosts use rhythms to defend against infection, why parasites have rhythms and whether parasites can manipulate host clocks to their own ends. Harnessing host rhythms or disrupting parasite rhythms could be exploited for clinical benefit; we propose an interdisciplinary effort to drive this emerging field forward.

Original languageEnglish (US)
Pages (from-to)552-560
Number of pages9
JournalNature Ecology and Evolution
Volume3
Issue number4
DOIs
StatePublished - Apr 1 2019

Bibliographical note

Funding Information:
We thank the Darwin Trust of Edinburgh (M.L.W.), the National Science Foundation (M.Z.), NERC and BBSRC (NE/K006029/1; S.E.R.), the Royal Society (UF110155; S.E.R.), and the Wellcome Trust (202769/Z/16/Z; S.E.R.) for supporting this work.

Publisher Copyright:
© 2019, Springer Nature Limited.

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