The EPR effect in cancer therapy

Ji Young Yhee, Sejin Son, Sohee Son, Min Kyung Joo, Ick Chan Kwon

Research output: Chapter in Book/Report/Conference proceedingChapter

40 Scopus citations


The enhanced permeability and retention (EPR) effect is the property which small sized nanoparticles and macromolecular drugs can accumulate more in tumor than in normal tissues. The EPR effect is generally due to the larger pore size of neo-vasculatures and poor lymphatic clearance of tumors, and it is strongly influenced by the size of small molecules including nanoparticles. The EPR effect has been considered as an alternative method for delivery of conventional anticancer drugs, and favorable bio-distribution of cancer therapeutic nanoparticles in blood would be considered to achieve a high level of accumulation in solid tumors. Based on the EPR concept, a variety of drugs in nano-carrier systems have been developed for cancer therapy. In this chapter, current progress and good examples for EPR effect-utilized anticancer therapy are reviewed.

Original languageEnglish (US)
Title of host publicationCancer Targeted Drug Delivery
Subtitle of host publicationAn Elusive Dream
PublisherSpringer New York
Number of pages12
ISBN (Electronic)9781461478768
ISBN (Print)1461478758, 9781461478751
StatePublished - Jul 1 2013

Bibliographical note

Publisher Copyright:
© 2013 Springer Science+Business Media New York. All rights reserved.


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