TY - JOUR
T1 - The epithelial-mesenchymal transition (EMT) is regulated by oncoviruses in cancer
AU - Chen, Xue
AU - Bode, Ann M.
AU - Dong, Zigang
AU - Cao, Ya
N1 - Publisher Copyright:
© FASEB.
PY - 2016/9
Y1 - 2016/9
N2 - The epithelial-mesenchymal transition (EMT), defined as transdifferentiation of epithelial cells into mesenchymal cells, is critical for embryonic development, wound healing, tissue regeneration, organ fibrosis, and cancer progression. Recently, the role of EMT in carcinogenesis has attracted much attention. Oncoviruses, includinghumanpapillomaviruses (HPVs), Epstein-Barr virus (EBV), andhepatitisBandCviruses (HBVs,HCVs), are known to be involved in the etiology of cancer and have been found to play important roles in cancer metastasis, especially in the EMT process. The HPV encoded oncoproteins E6 and E7 (E6/E7), EBV latent membrane protein-1 and -2A, EBV nuclear antigen, HBV-encoded X antigen, and nonstructural HCV protein 5A are all involved in the regulation of EMT. This reviewprimarily focuses on the role of oncoviruses and their encoded proteins or signaling pathways in the EMT process. Understanding their roles will help us in the development of effective strategies for prevention and treatment of virus-related cancers.-Chen, X., Bode, A. M., Dong, Z., Cao, Y. The epithelial- mesenchymal transition (EMT) is regulatedby oncoviruses in cancer. FASEBJ. 30, 3001-3010 (2016).www.fasebj.org.
AB - The epithelial-mesenchymal transition (EMT), defined as transdifferentiation of epithelial cells into mesenchymal cells, is critical for embryonic development, wound healing, tissue regeneration, organ fibrosis, and cancer progression. Recently, the role of EMT in carcinogenesis has attracted much attention. Oncoviruses, includinghumanpapillomaviruses (HPVs), Epstein-Barr virus (EBV), andhepatitisBandCviruses (HBVs,HCVs), are known to be involved in the etiology of cancer and have been found to play important roles in cancer metastasis, especially in the EMT process. The HPV encoded oncoproteins E6 and E7 (E6/E7), EBV latent membrane protein-1 and -2A, EBV nuclear antigen, HBV-encoded X antigen, and nonstructural HCV protein 5A are all involved in the regulation of EMT. This reviewprimarily focuses on the role of oncoviruses and their encoded proteins or signaling pathways in the EMT process. Understanding their roles will help us in the development of effective strategies for prevention and treatment of virus-related cancers.-Chen, X., Bode, A. M., Dong, Z., Cao, Y. The epithelial- mesenchymal transition (EMT) is regulatedby oncoviruses in cancer. FASEBJ. 30, 3001-3010 (2016).www.fasebj.org.
KW - Cancer progression
KW - Carcinogenesis virus
KW - Metastasis
KW - Signaling pathway
UR - http://www.scopus.com/inward/record.url?scp=84990179542&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84990179542&partnerID=8YFLogxK
U2 - 10.1096/fj.201600388R
DO - 10.1096/fj.201600388R
M3 - Review article
C2 - 27279361
AN - SCOPUS:84990179542
SN - 0892-6638
VL - 30
SP - 3001
EP - 3010
JO - FASEB Journal
JF - FASEB Journal
IS - 9
ER -
