The endosomal trafficking regulator LITAF controls the cardiac nav1.5 channel via the ubiquitin ligase NEDD4-2

Keyphrases

• Ubiquitin Ligase 100%
• Lipopolysaccharide-induced 100%
• Tumor Necrosis Factor-α 100%
• NEDD4 100%
• Endosomal Trafficking 100%
• Cardiac Sodium Channel Nav1.5 100%
• Factors Control 100%
• Nav1.5 58%
• HEK Cells 33%
• QT Interval 25%
• Genome-wide Association Study 16%
• Cardiomyocytes 16%
• Action Potential Duration 16%
• Homeostasis 8%
• Overexpression 8%
• Zebrafish 8%
• Genetic Variants 8%
• Surface Proteins 8%
• Negative Effects 8%
• Protein Level 8%
• Protein-coding Genes 8%
• Colocalization 8%
• Cardiac Electrical Activity 8%
• Stably Expressing 8%
• In Vitro Data 8%
• Proteasomal Degradation 8%
• Computational Data 8%
• Induced Voltage 8%
• Voltage-gated Sodium Channel 8%
• Voltage-gated Sodium Current 8%
• Cardiac Depolarization 8%
• Cardiac Excitability 8%
• Cardiomyocyte Model 8%
• Proximity Ligation Assay 8%
• Co-immunoprecipitation (co-IP) 8%
• Cardiomyocyte Cell 8%
• Ubiquitination Degradation 8%
• Cardiac Excitation 8%

Biochemistry, Genetics and Molecular Biology

• NEDD4 100%
• Nav1.5 100%
• Tumor Necrosis Factor Alpha 100%
• Lipopolysaccharide 100%
• Ubiquitin Ligase 100%
• Cardiac Muscle Cell 33%
• QT Interval 25%
• Electric Potential 16%
• Leporidae 16%
• Action Potential Duration 16%
• Genome-Wide Association Study 16%
• Genetic Divergence 8%
• Immunoprecipitation 8%
• Electric Activity 8%
• Zebra Fish 8%
• Homeostasis 8%
• Ubiquitination 8%
• Heart Depolarization 8%
• Sodium Current 8%
• Heart Muscle Excitability 8%
• Sodium Channel 8%
• Computer Simulation 8%
• Colocalization 8%